Abstract
Introduction: Regulatory T lymphocytes have an effective role in induction of immune tolerance and angiogenesis during pregnancy. Differentiation and replication of these lymphocytes from other T cells is controlled by FOXP3 transcriptional factor. FOXP3 gene is polymorphic. Objectives: This study was designed to investigate the role FOXP3 common polymorphisms in susceptibility to preeclampsia in Lur populations of Lorestan province of Iran. Patients and Methods: This study was conducted on three polymorphisms rs2232365 A/G, rs3761548 C/A and rs5902434 del/ATT using polymerase chain reaction with sequence specific primers (PCR SSP). A total of 100 participants were subjected to be studied. Data analysis was done using Fisher’s exact test and multivariate logistic regression. Results: In rs2232365 polymorphism, AA genotype was a risk factor (P=0.002) and AG genotype was a protecting factor (P<0.001). In polymorphism of rs3761548, CA genotype was a risk factor (P=0.036) and AA genotype was a protecting factor (P=0.015). In polymorphism rs5902434, del/del genotype was a risk factor (P=0.013) and del/ATT genotype was a protecting factor (P<0.001). After adjusting the effects of genotypes, CA genotype of rs3761584 polymorphism was considered as an attributable risk factor (P=0.040; odds ratio [OR] =4.19). Conclusion: The present population showed a unique association for the role of FOXP3 polymorphism in susceptibility to preeclampsia in comparison to previous studies.
Highlights
Regulatory T lymphocytes have an effective role in induction of immune tolerance and angiogenesis during pregnancy
Preeclampsia is called as a new onset hypertension after gestational age of 20 weeks along with a sign of organ damage which was previously defined as proteinuria
For polymorphism of rs2232365, forkhead box protein 3 (FOXP3) gene polymorphisms frequency of the wild type allele (A) was more than 50%
Summary
Regulatory T lymphocytes have an effective role in induction of immune tolerance and angiogenesis during pregnancy. Objectives: This study was designed to investigate the role FOXP3 common polymorphisms in susceptibility to preeclampsia in Lur populations of Lorestan province of Iran. Results: In rs2232365 polymorphism, AA genotype was a risk factor (P = 0.002) and AG genotype was a protecting factor (P < 0.001). In polymorphism of rs3761548, CA genotype was a risk factor (P = 0.036) and AA genotype was a protecting factor (P = 0.015). In polymorphism rs5902434, del/del genotype was a risk factor (P = 0.013) and del/ATT genotype was a protecting factor (P < 0.001). Conclusion: The present population showed a unique association for the role of FOXP3 polymorphism in susceptibility to preeclampsia in comparison to previous studies. Preeclampsia is called as a new onset hypertension after gestational age of 20 weeks along with a sign of organ damage which was previously defined as proteinuria. The etiology of preeclampsia is not clear; its pathophysiology has an immunological basis [3]
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