Association of FOXF2 gene polymorphisms with ischemic stroke in Chinese Han population.

Chang-He Shi,Yu-Ming Xu,Xin-Jing Liu,Yuan Gao,Bo Song,Yu-Sheng Li,Jun Wu,Lu Zhao,Shi-Lei Sun,Mi-Bo Tang,Zhi-Jie Wang,Shao-Hua Li

doi:10.18632/oncotarget.21263

Abstract

Recently, a novel locus at chromosome 6p25 (rs12204590, near FOXF2) associated with an increased risk of stroke in European populations was identified. However, whether polymorphisms in FOXF2 are also associated with the incidence of ischemic stroke in other populations remains unknown. In this case-control study, 803 Chinese Han patients with ischemic stroke and 803 matched control individuals were enrolled. Four tag SNPs and rs12204590 located in or near FOXF2 were selected, and the associations between genotypes/alleles and ischemic stroke were analyzed. In our study, we did not detect an association between the previously reported locus rs12204590 and ischemic stroke. By the genotype analysis, a novel SNP rs1711972, near FOXF2, was observed to be associated with an increased risk of ischemic stroke(CA genotype, adjusted OR = 1.35; 95% CI, 1.07 to 1.70), but not significantly after Bonferroni corrections for multiple tests. However, in the subgroup analysis, we discovered that rs1711972 was associated with an increased risk of large-artery atherosclerotic stroke in the additive model (P = 0.020; CA genotype, adjusted OR = 1.50; 95%CI, 1.09 to 2.07) and dominant model (P = 0.010; OR = 1.47; 95%CI, 1.09 to 1.99). Collectively, these results indicate that a novel SNP near FOXF2 may influence the risk of large-artery atherosclerotic stroke in Chinese Han population.

Highlights

Stroke is the leading neurological cause of death and long-term disability worldwide [1, 2]
As large-artery atherosclerotic (LAA) stroke and small-vessel disease (SVD)-related stroke are the most pervasive subtypes in the Chinese Han population [21], and increasing evidence has revealed that the genetic risks vary depending on the subtypes of ischemic stroke [22], it is important to determine whether the variants in or near FOXF2 are associated with the increased risk of ischemic stroke and its subtypes
There was a significant deviation with respect to the history of hypertension (P < 0.01) and diabetes mellitus (DM) (P < 0.01) revealed between the patient and control groups

Summary

INTRODUCTION

Stroke is the leading neurological cause of death and long-term disability worldwide [1, 2]. A novel locus at chromosome 6p25 (rs12204590, near FOXF2) has been observed to be associated with an increased risk of stroke in European populations [18]. It has been revealed that chromosome 6p25.3 is associated with an increase in the appearance of white matter hyperintensities in the general population [18]. Patients with rare segmental deletions of FOXF2 exhibited an increased appearance of white matter hyperintensities. To investigate the possible role of rs12204590 and other new loci in or near FOXF2 that are associated with ischemic stroke, a case-control study of 803 cases and 803 controls was performed

RESULTS

DISCUSSION

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