Abstract
Parkinson disease (PD) is a neurological disorder with huge destruction to human body, which affects approximately 2% of the population aged 65 years or older. As antioxidants in the stress defence systems, glutathione S-transferases (GSTs) are dimeric cytosolic enzymes with an important role in the pathogenesis of PD. The aim of this study was to evaluate the association between the polymorphisms of GST genes and PD. Meta-analyses were conducted from 17 studies (38 stages) among 3419 cases and 5686 controls between four polymorphisms (GSTT1 deletion polymorphism; GSTM1 deletion polymorphism; GSTP1-104: rs1695; GSTP1-114: rs1799811) and PD. There is no significant association between the four GST gene variants and PD. A further subgroup study by ethnicity observed a risky role of GSTM1 deletion polymorphism with PD in Europeans (p = 0.013, OR = 1.126, 95% CI = 1.025-1.236), and a protective role of GSTM1 deletion polymorphism with PD in Latin Americans (p = 0.032, OR = 0.750, 95% CI = 0.577-0.975). Our meta-analysis suggested that GSTM1 deletion polymorphism increased the risk of PD in Europeans, but reduced the risk of PD in Latin Americans. Future large-scale studies might be needed to confirm the ethnic difference of GSTM1 deletion polymorphism, and to check whether there was significant association of PD for other GST genetic polymorphisms.
Highlights
Parkinson disease (PD, OMIM 168600) is a neurological disorder that affects approximately 2% of the population aged 65 years or older [1]
Our meta-analyses showed that GSTM1 deletion polymorphism was a risky and protective factor in PD for Europeans and Latin Americans, respectively (Table 2 and Figure 2)
Homozygous deletion genotypes of GSTM1 and GSTT1 were relatively common in Caucasian populations [54], and disease prevalence by WHO showed that Europe was the most severe region of PD in the world
Summary
Parkinson disease (PD, OMIM 168600) is a neurological disorder that affects approximately 2% of the population aged 65 years or older [1]. The clinical features of PD are resting tremor, muscular rigidity, bradykinesia, and postural instability [2]. PD can cause a huge destruction to human body, including pain [3], depression [4,5], visual hallucinations [6], dementia [7] and other non-motor symptoms [8,9,10,11]. PD is a complex disease that may be contributed by environmental and genetic factors. Environmental hypothesis was dominant for much of the 20th century [2]. PD was shown to be associated with environmental factors such as encephalitis [12], oxidative stress [13], smoking and coffee [14], and environmental toxins [15]. Recent genetic studies have discovered a handful of genetic markers of PD [16,17,18], the aetiology of PD remains unknown
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
