Association of food intake with prostate cancer aggressiveness of African and Caucasian Americans in a population‐based study

Abstract

This study aimed to determine the association between major food groups that contribute to antioxidant intake and prostate cancer aggressiveness (PCA). Data are from the North Carolina‐Louisiana Prostate Cancer Project, a study of incident prostate cancer in African Americans (AA) (n=925) and Caucasian Americans (CA) (n=1,059). Dietary data were collected by a modified NCI DHQ. Prostate cancer cases were classified as low aggressive (LA) (Gleason score <7, stage ≤T2, PSA <10 ng/ml), high aggressive (HA) (Gleason score ≥8; PSA ≥20 ng/ml; or Gleason score = 7 if stage ≥T3), or intermediate aggressive (IA) (others). AA consuming 1 to 2 cups of fruit drink a week were found to have an odds ratio (OR) for HA vs. LA of 0.43 (95% CI: 0.20, 0.96) and 1 to 2 glasses of wine a week were found to have an OR for IA vs. LA of 0.30 (95% CI: 0.09, 1.00). CA drinking >;2 cups a day of tea were found to have an OR for HA vs. LA of OR 0.44 (95% CI: 0.20, 0.94) and 1 to 2 cups a week of orange juice were found to have an OR for IA vs. LA of OR 0.52 (95% CI: 0.27, 0.98). These results imply that antioxidant rich foods may contribute differently to PCA in CA and AA.Grant Funding Source: NIH Cancer Epidemiology Small Grant #1R03CA159421–01A1.