Abstract
IntroductionThe role of vitamin D in placental functions and fetal growth had been addressed in many reports with conflicting results. However, such report is limited for Indonesian population. The aim of this study was to explore the association between maternal vitamin D level in the first trimester and fetal biometry in the later stage of pregnancy with adjusted OR for other determinants like hemoglobin and ferritin level.MethodsFrom July 2016 a prospective cohort study of pregnant women had begun in four cities in West Java, Indonesia. Data on maternal vitamin D, ferritin, hemoglobin level, maternal demography and fetal biometry were analyzed with linear regression.ResultsAmong 203 recruited women, 195 (96.06%) had hypovitaminosis D. One hundred fifty two (75%) were in deficient state and 43 women (21%) were in insufficient state. Women with insufficient vitamin D had the highest proportion of anemia, while women with normal vitamin D level had the highest proportion of low ferritin level. Maternal serum vitamin D showed significant associations with biparietal diameter (β = 0.141, p = 0.042) and abdominal circumference (β = 0.819, p = 0.001) after adjustment with maternal age, pre-pregnancy body mass index, parity, serum ferritin level, and hemoglobin level.ConclusionOur study suggested that sufficient maternal vitamin D level was an important factor to improve fetal growth and development.
Highlights
The role of vitamin D in placental functions and fetal growth had been addressed in many reports with conflicting results
Most nutritional status as defined by pre-pregnancy body mass index was within normal value
A larger proportion of pregnant women who were underweight were at higher risk of anemia as a result of chronic undernourishment than those who were obese
Summary
The role of vitamin D in placental functions and fetal growth had been addressed in many reports with conflicting results. The aim of this study was to explore the association between maternal vitamin D level in the first trimester and fetal biometry in the later stage of pregnancy with adjusted OR for other determinants like hemoglobin and ferritin level. Fetal growth and development is highly influenced by maternal nutrition state before and during pregnancy. A study has shown that vitamin D’s main role is in muscle, bone and mineral homeostasis especially related to calcium regulation [5]. Other study confirmed that vitamin D was an important regulator for osteoblast activity in various skeletal sites [8]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
