Association of First-Trimester Fasting Plasma Glucose with Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes

Abstract

This study aims to evaluate the usefulness of a fasting plasma glucose (FPG) at the first trimester in predicting gestational diabetes mellitus (GDM) and the association between FPG and adverse pregnancy outcomes in Chinese women. Medical records of 2112 singleton pregnant women were collected from the third affiliated hospital of Sun Yat-Sen University, Guangzhou, China, from January 2016 to June 2017. FPG was measured at 9-13+6 weeks and 75 g oral glucose tolerance test (OGTT) was performed at 24-28 weeks in each subject. The International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria was used for diagnosing GDM. Among 2112 subjects, 224 (10.6%) subjects were diagnosed with GDM. The area under ROC curve (AUC) for FPG in predicting GDM was 0.63 (95% CI 0.61- 0.65) and the optimal cutoff value 4.5 mmol/L (sensitivity 64.29% and specificity 56.45%) (Figure 1). Higher first-trimester FPG increased the incidences of GDM, large for gestational age (LGA) and assisted vaginal delivery and/or cesarean section (all P > 0.05). These results suggested FPG at first trimester could be used to predict GDM and higher first-trimester FPG was associated with adverse pregnancy outcomes. Disclosure P. Li: None. S. Lin: None. L. Li: None. J. Cui: None. J. Fan: None.