Abstract
The fibroblast growth factor (FGF) receptor pathway is activated in many tumors. FGFR2 has been identified as a breast cancer susceptibility gene. Common variation in other FGF receptors might also affect breast cancer risk. We carried out a case-control study to investigate associations of variants in FGFR3 and FGFR4 with breast cancer in women from Heilongjiang Province. SNP rs2234909 and rs3135848 in FGFR3 and rs1966265 and rs351855 in FGFR4 were successfully genotyped in 747 breast cancer patients and 716 healthy controls using the SNaPshot method. The associations between SNPs and breast cancer were examined by logistic regression. The associations between SNPs and disease characteristics were examined by chi-square tests or one-way ANOVA as needed. The minor alleles of rs1966265 and rs351855 in FGFR4 were strongly associated with breast cancer in the population, with odds ratios of 1.335 (95%CI = 1.154-1.545) and 1.364 (95%CI = 1.177-1.580), respectively. However, no significant associations were detected between other SNPs and breast cancer. Analyses of the disease characteristics showed that SNP rs351855 was associated with lymph-node-positive breast cancer with a dose-dependent effect of the minor allele (P = 0.008). SNPs rs1966265 and rs351855 in FGFR4 were associated with breast cancer in a northern Chinese population.
Highlights
Breast cancer is a complex disease and one of the most common malignancies in women worldwide
SNPs rs1966265 and rs351855 in FGFR4 were associated with breast cancer in a northern Chinese population
We hypothesized that common variants in other genes in the fibroblast growth factor (FGF) pathway might raise breast cancer risk, and we carried out this case-control study to identify associations between breast cancer risk and common variants in the FGF receptor genes FGFR3 and FGFR4 by genotyping www.impactjournals.com/oncotarget
Summary
Breast cancer is a complex disease and one of the most common malignancies in women worldwide. Genome-wide association studies have identified an intronic variant in the FGFR2 gene as a breast cancer susceptibility locus [3, 4]. More studies have strongly suggested that FGFR2 is a breast cancer susceptibility gene [5,6,7,8]. FGFR2 belongs to the human fibroblast growth factor (FGF) and receptor family, which consists of genes that play critical roles in cancer development due to their angiogenic potential and direct enhancement of tumor growth [9]. FGFR2 has been identified as a breast cancer susceptibility gene. We carried out a case-control study to investigate associations of variants in FGFR3 and FGFR4 with breast cancer in women from Heilongjiang Province
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
