Association of fat patterning, hypertension and ACE (I/D) gene polymorphism: a study on two Tibeto-Burman linguistic group of Tripura, North East India

Abstract

Background Hypertension is considered as a major cause of morbidity and mortality throughout the world and become a major global burden on public health in many developing countries Regulation of blood pressure is a complex process Apart from environmental factors multiple genes have been responsible for hypertension The gene environment and fat patterning interaction in the pathogenesis of hypertension has not been extensively studied in the north east Indian ethnic groups Aim In this context to best of our knowledge this is a maiden attempt to discern the association between fat patterning blood pressure and ACE I D gene polymorphism among the two Tibeto Burman speaking ethnic groups Chakmas and Tripuris of North East India Tripura Materials and methods To achieve the purpose total Chakma and Tripuri apparently healthy unrelated adult males from Tripura North East India were incorporated in the present study Anthropometric variables and physiological variables blood pressure have been collected using standard techniques Extracted genomic DNA from mouthwash was PCR amplified and genotyped to understand ACE gene I D polymorphism Results Examination on the association of fat patterning and hypertension revealed significantly p lt higher hypertensive individuals and accumulation of central obesity among the Chakmas compared to the Tripuris ACE I D gene polymorphism demonstrated higher frequency of lsquo I rsquo allele in the present study groups and the findings of the present study is in agreement with the distributions found in Asiatic populations and also in close corroboration with other Tibeto Burman linguistics groups of North East India Conclusion Significantly p lt higher hypertensive individuals were found among the Chakmas in comparison to the Tripuris The present study envisaged central adiposity is a major risk factor for hypertension in Chakmas rather than ACE I D polymorphism