Abstract
Background: Atrial natriuretic peptide increases lipolysis in human adipocytes by binding to natriuretic peptide receptor-A (NPRA). The aim of the current study was to examine the associations of NPRA mRNA of subcutaneous adipose tissue with fat mass, fat-free mass, body mass index (BMI) and arterial blood pressure in medication-free healthy men. Method: Thirty-two volunteers [age (years): 36.06±7.36, BMI: 27.60±4.63 (kg/m 2)] underwent assessments of body height/weight, % fat mass, fat-free mass (kg), blood pressure, and a subcutaneous adipose tissue biopsy via a surgical technique. Results: We found that NPRA mRNA was negatively associated with % fat mass (r=-0.40, R 2=0.16, p=0.03) and BMI (r=-0.45, R 2=0.20, p=0.01). Cohen's f 2 effect size analyses showed a small effect size between NPRA mRNA and BMI ( f 2 =0.25). One-way analysis of variance with Bonferroni post-hoc tests showed a tendency for mean differences of NPRA mRNA across BMI categories (p=0.06). This was confirmed by Cohen's d effect size analyses revealing a large effect size of NPRA mRNA between obese individuals (BMI≥30 kg/m 2) and either normal weight (BMI=19-25 kg/m 2; d=0.94) or overweight (BMI=25-30 kg/m 2; d=1.12) individuals. Conclusions: NPRA mRNA is negatively associated with % fat mass and BMI in medication-free healthy men, suggesting a possible role of NPRA in the control of fat mass accumulation.
Highlights
Atrial natriuretic peptide (ANP) lowers arterial pressure to maintain fluid volume homeostasis, protecting against renal and cardiac pathogenesis[1]
The natriuretic peptide receptor-A (NPRA) mRNA was negatively correlated with %fat mass (FM) (r=-0.40, p=0.03) (Figure 1) and body mass index (BMI) (r=-0.45, p=0.01) (Figure 2)
No associations were found between NPRA mRNA and fat-free mass (FFM), systolic or diastolic blood pressure (BP) (p>0.05)
Summary
Atrial natriuretic peptide (ANP) lowers arterial pressure to maintain fluid volume homeostasis, protecting against renal and cardiac pathogenesis[1]. The aim of the current study was to examine the associations of NPRA mRNA of SAT with fat mass, fat-free mass (FFM), body mass index (BMI) and arterial blood pressure (BP) in medication-free healthy men. The aim of the current study was to examine the associations of NPRA mRNA of subcutaneous adipose tissue with fat mass, fat-free mass, body mass index (BMI) and arterial blood pressure in medication-free healthy men. One-way analysis of variance with Bonferroni post-hoc tests showed a tendency for mean differences of NPRA mRNA across BMI categories (p=0.06) This was confirmed by Cohen’s d effect size analyses revealing a large effect size of NPRA mRNA between obese individuals (BMI≥30 kg/m2) and either normal weight (BMI=19-25 kg/m2; d =0.94) or overweight (BMI=25-30 kg/m2; d=1.12) individuals
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