Association of FAS Gene Promoter Functional Polymorphisms and the Risk of Vitiligo in Turkish Populations

Abstract

Background: The FAS/FASLG system shows a key role in regulating apoptosis. Objectives: Previous findings have indicated that a significantly increased risk of vitiligo was associated with FAS-1377 AA genotype and the FAS-1377 AG genotype when compared with FAS1377 GG genotype in Chinese population. Material and Methods: We investigated the FAS-670, FAS-1377, FAS-844 and FAS-124 polymorphisms in 113 vitiligo patients and also compared 196 controls. Results: We found that a significantly increased vitiligo was associated with the FAS-670 GA genotype [adjusted odds ratio (OR), 2.87; 95% confidence interval (CI), 1.37-6.03] when compared with the controls. However, there were no evident risk associated with FAS-1377, 844 and 124 genotypes. Conclusion: This is the first report of an association between FAS-670, FAS-1377, FAS-844 and FAS124 gene polymorphism and vitiligo in a Turkish population. The results of this study suggest that the presence of FAS-670 GA genotype can be regarded as risk factor for vitiligo, and especially for vitiligo in Turkish population.