Abstract
Background: Breast cancer is the most common cancer among women. The Korean Genome and Epidemiology Study (KoGES) is a large cohort study that is available to the public. Using this large cohort study, we aimed to unravel the relationship between breast cancer development and a family history of breast cancer in Korea. Methods: This cohort study relied on data from the KoGES from 2001 through 2013. A total of 211,725 participants were screened. Of these, 129,374 women were evaluated. They were divided into two groups, including participants with and without breast cancer. A logistic regression model was used to retrospectively analyze the odds ratio of breast cancer history in families of women with and without breast cancer. Results: Of 129,374 women, 981 had breast cancer. The breast cancer group had more mothers and siblings with histories of breast cancer (p < 0.001). A history of breast cancer in the participant’s mother resulted in an odds ratio of 3.12 (1.75–5.59), and a history of breast cancer in the participant’s sibling resulted in an odds ratio of 2.63 (1.85–3.74). There was no interaction between the history of maternal breast cancer and the history of sibling breast cancer. Based on the subgroup analysis, family history was a stronger factor in premenopausal women than in menopausal and postmenopausal women. Conclusions: A family history of breast cancer is a significant risk factor for breast cancer in Korea. Premenopausal women with a maternal history of breast cancer are of particular concern. Intensive screening and risk-reducing strategies should be considered for this vulnerable subpopulation.
Highlights
Breast cancer is the most common cancer among women [1,2]
This cohort study relied on data from the Korean Genome and Epidemiology Study (KoGES) from 2001 through 2013
Among women with breast cancer were more family histories observed in the group with onset ages less than 50 years, the results were not statistically significant
Summary
Breast cancer is the most common cancer among women [1,2]. The incidence of breast cancer in Korea was at 5848 cases in 2000 [3]. The incidence rate of breast cancer in Korea is steadily increasing even though it is still lower than the rates in Western countries [3,4,5]. Since 2016, over 20,000 individuals per year have been diagnosed with breast cancer in. The number of breast cancer cases in the United States rises with increasing patient age [1,2]. In Korea, the peak is observed at 40–49 years of age and decreases after the age of
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