Abstract
Association of estrogen and progesterone with cancer of the uterine cervix in women infected with high-risk human papillomavirus
Highlights
Cervical cancer is the fourth most common cancer affecting women and seventh overall worldwide [1]
The serum levels of progesterone were significantly increased in premenopausal cases as compared to premenopausal controls (p
A significantly elevated levels of progesterone is associated with cervical cancer in premenopausal women infected with High-risk human papillomavirus (HR-human papillomavirus (HPV))
Summary
Cervical cancer is the fourth most common cancer affecting women and seventh overall worldwide [1]. About 70% of the global burden falls in developing countries and more than one fifth of all new cases are diagnosed in India. In India, it is the most common cancer among women with more than 130,000 new cases and 70,000 deaths occurring every year [2]. Cervical cancer is usually preceded by a long pre invasive phase, known as dysplasia. Specific genotypes of human papillomavirus (HPV) are the single most etiological agents of cervical intraepithelial lesions and cervical cancer [4, 5]. High-risk human papillomavirus (HR-HPV) infection is essential for the development of dysplasia and cervical cancer. The aim of the present study is to investigate the association of serum levels of estrogen and progesterone with cervical cancer in HR-HPV infected women
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