Abstract
The relationship between ERCC gene polymorphism and osteosarcoma risk / overall survival of osteosarcoma is still conflicting, and this meta-analysis was performed to assess these associations. The association studies were identified from PubMed, and eligible reports were included and calculated using meta-analysis method. Four studies were included for the association of ERCC gene polymorphism with osteosarcoma risk, and nine studies were recruited into this meta-analysis for the relationship between ERCC gene polymorphism and overall survival of osteosarcoma. The meta-analysis indicated that ERCC1 rs3212986 (8092 C>A) gene polymorphism, ERCC1 rs11615 (19007 T>C) gene polymorphism, ERCC2 rs1799793 (A>G) gene polymorphism, ERCC2 rs13181 (Lys751Gln) gene polymorphism were not associated with osteosarcoma risk. ERCC1 rs2298881 (C>A) gene polymorphism, ERCC1 rs3212986 (8092 C>A) gene polymorphism, ERCC1 rs11615 (19007 T>C) gene polymorphism, ERCC2 rs1799793 (Asp312Asn) gene polymorphism were not associated with overall survival of osteosarcoma. Interestingly, ERCC2 rs13181 A allele and GG genotype were associated with overall survival of osteosarcoma, but AA genotype not (A allele: OR = 0.78, 95% CI: 0.65-0.93, P = 0.007; GG genotype: OR = 1.32, 95% CI: 1.05-1.65, P = 0.02; AA genotype: OR = 0.69, 95% CI: 0.45-1.04, P = 0.08). ERCC2 rs13181 A allele and GG genotype were associated with overall survival of osteosarcoma.
Highlights
The relationship between Excision repair cross-complementation (ERCC) gene polymorphism and osteosarcoma risk / overall survival of osteosarcoma is still conflicting, and this meta-analysis was performed to assess these associations
We found that ERCC1 rs3212986 (8092 C>A) gene polymorphism was not associated with osteosarcoma risk (A allele: odds ratios (OR) = 0.79, 95% confidence intervals (CI): 0.56-1.12, P = 0.18; AA genotype: OR = 0.68, 95% CI: 0.30-1.57, P = 0.37; CC genotype: OR = 1.05, 95% CI: 0.78-1.40, P = 0.76)
We found that ERCC2 rs13181 (Lys751Gln) gene polymorphism was not associated with osteosarcoma risk (A allele: OR = 1.8, 95% CI: 0.93-1.78, P = 0.13; AA genotype: OR = 1.01, 95% CI: 0.72-1.43, P = 0.94; GG genotype: OR = 0.79, 95% CI: 0.53-1.17, P = 0.24)
Summary
The relationship between ERCC gene polymorphism and osteosarcoma risk / overall survival of osteosarcoma is still conflicting, and this meta-analysis was performed to assess these associations. Results: Four studies were included for the association of ERCC gene polymorphism with osteosarcoma risk, and nine studies were recruited into this meta-analysis for the relationship between ERCC gene polymorphism and overall survival of osteosarcoma. The meta-analysis indicated that ERCC1 rs3212986 (8092 C>A) gene polymorphism, ERCC1 rs11615 (19007 T>C) gene polymorphism, ERCC2 rs1799793 (A>G) gene polymorphism, ERCC2 rs13181 (Lys751Gln) gene polymorphism were not associated with osteosarcoma risk. ERCC1 rs2298881 (C>A) gene polymorphism, ERCC1 rs3212986 (8092 C>A) gene polymorphism, ERCC1 rs11615 (19007 T>C) gene polymorphism, ERCC2 rs1799793 (Asp312Asn) gene polymorphism were not associated with overall survival of osteosarcoma. Association of ERCC gene polymorphism with osteosarcoma risk. Within DNA repair genes, there lie a number of single nucleotide polymorphisms which may impair protein function and attenuate DNA repair capability, resulting in genomic instability and individual predisposition to
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