Abstract
Objective: Metals including arsenic, lead, mercury, and cadmium are toxic and can increase cardiovascular disease risk. High-sensitivity C-reactive protein (hs-CRP) is a biomarker for inflammation and cardiovascular risk. This study will evaluate the association between urinary speciated arsenic, cadmium, lead, and mercury and blood values of hs-CRP in the United States adult population. Methods: A cross-sectional study using the 2015-2016 NHANES dataset, conducting multivariate linear regressions to analyze selected urinary metals and links with serum hs-CRP. Results: The sample consisted of 780 adults. In adjusted models, arsenocholine was found to be protective of inflammation, whereas aresnous acid, which is an inorganic, toxic type of arsenic acid, was positively associated with hs-CRP (b = 2.53). Conclusion: Urinary arsenous acid is a significant predictor of hs-CRP which is a biomarker for CVD.
Highlights
Arsenic is a human carcinogen linked to bladder, skin, and lung cancers, skin lesions, and depression [1] [2]
After removal of participants (n = 11) with High-sensitivity C-reactive protein (hs-C-reactive protein (CRP)) values greater than three standard deviations above the mean, the adjusted hs-CRP for the sample was 3.67 + 4.44, indicating that the average participant had high above normal systemic inflammation
Our study found no association between urinary lead and hs-CRP in the unadjusted or adjusted models
Summary
Arsenic is a human carcinogen linked to bladder, skin, and lung cancers, skin lesions, and depression [1] [2]. Arsenic has been associated with arsenicrelated cardiovascular disease suggesting that arsenic exposure leads to thrombosis and inflammation [3]. In addition to contaminated water, arsenic exposure can occur through foods including rice and apple juice [1]
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