Abstract
BackgroundInfection is the second most common cause of mortality for patients with end-stage renal disease (ESRD), accompanying with immune dysfunction. Endothelin (EDN) is known to be related to inflammation; however, it is unknown whether genetic variants of the EDN gene family are associated with increased risk of hospitalized infection events.MethodsNineteen tagging single-nucleotide polymorphisms (tSNPs) of the EDN gene family were selected for genotyping a cohort of 190 ESRD patients. Patient demographics were recorded, the subtypes of infection events were identified, and association analysis between the EDN genetic variants and hospitalized infection events was performed.ResultsIn this study, 106 patients were hospitalized for infection events. The leading events were pneumonia, bacteremia, and cellulitis. The minor allele of rs260741, rs197173, and rs926632 SNPs of EDN3 were found to be associated with reduced risk of hospitalized bacteremia events.ConclusionsThe minor allele of rs260741, rs197173, and rs926632 in EDN3 were associated with reduced risk of hospitalized bacteremia events in ESRD patients.
Highlights
Infection is the second most common cause of mortality for patients with end-stage renal disease (ESRD), accompanying with immune dysfunction
Ferwerda et al reported that the genetic variants of Toll-like receptor 4, which underlies the differential production of cytokines may affect the immune system, which in turn influenced the susceptibility of infection events and the risk of gram-negative bacterial infection [6]
Clinical characteristics of patients A total of 190 ESRD patients were enrolled at Taipei Medical University Hospital
Summary
Infection is the second most common cause of mortality for patients with end-stage renal disease (ESRD), accompanying with immune dysfunction. Endothelin (EDN) is known to be related to inflammation; it is unknown whether genetic variants of the EDN gene family are associated with increased risk of hospitalized infection events. Infection is known as a common cause of morbidity and mortality in patients with end-stage renal disease (ESRD), accounting for 20% of total deaths in these patients [1]. Genetic variants of immune-related genes have been shown to reflect risk of infection. Ferwerda et al reported that the genetic variants of Toll-like receptor 4, which underlies the differential production of cytokines may affect the immune system, which in turn influenced the susceptibility of infection events and the risk of gram-negative bacterial infection [6]. Another study demonstrated that an IL-9 variant may influence the susceptibility of respiratory syncytial virus infection [7]
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