Association of dyslipidemia with psoriasis: A case-control study

Abstract

Background: Psoriasis has recently been recognized as a systemic disease associated with several comorbidities such as obesity and dyslipidemia. These markers have a profound effect on cardiovascular morbidity. Objectives: We aim to evaluate the lipid profiles in patients of psoriasis and compare them with healthy controls to determine any association between psoriasis and lipid abnormalities. Materials and Methods: A case-control study was performed on a study group including 33 patients of clinically proven psoriasis and an equal number of age- and sex-matched healthy volunteers, taken as controls. The fasting serum lipid profile was estimated using J & J Vitros 250 Chemical Analyser (Ortho-Clinical Diagnostics), fully automated analyzer, after a period of 8-12 h of fasting. The data were analyzed by applying t-test for independent samples and Pearson's correlation by using GraphPad. Results: High-density lipoprotein cholesterol levels were found to be significantly lower in cases than in the control group (P = 0.028). There was a significant positive correlation between triglyceride (TG) levels and Psoriasis Area Severity Index or severity of the disease (r = 0.36, P = 0.036). No significant statistical difference was observed between total cholesterol, TGs, and low-density lipoprotein levels of the cases and control groups. Conclusion: The findings demonstrated a possible association between psoriasis and dyslipidemia which underlines the need for early screening of psoriasis patients for this cardiovascular risk factor.