Association of Distal Deletion of the Short arm of Chromosome 9 with 46,XY Disorder of Sex Development and Gonadoblastoma

Del Rey G Venara M

doi:10.4172/2329-6577.1000129

Abstract

Deletion of the short arm of chromosome 9 is associated with two distinct clinical prototypes. Small telomeric distal 9p deletions have been reported in patients 46,XY with gonadal dysgenesis, this region contains genes required in two copies for normal testis development. Recent studies have narrowed the interval 9p24.3-pter containing the putative autosomal testis-determining gene(s) known as domain DMRT. On the other hand, and depending on the extent of deletion of the short arm, the clinical characteristics of monosomy 9p syndrome may emerge. We present an infant female with complete 46,XY gonadal dysgenesis, who was examined for motor developmental retardation. In the karyotype a chromosomal deletion 9p24.1 was identified by cytogenetic and fluorescence in situ hybridization studies. No SRY deletion or mutation was detected. Ultrasonographic studies showed a normal uterus. Basal luteinizing hormone and follicle stimulating hormone values were high. The patient underwent gonadectomy at 3.2 years of age, and histologic analysis disclosed dysgenetic gonads with gonadoblastoma.

Highlights

Disorders of sex development (DSD) are congenital conditions which result in discordance between genetic, gonadal and phenotypic sex
Other genes are implicated in gonadal development, some of which are located in autosomic chromosomes, such as DMRT in 9p (OMIM 602424)
We report a patient with 46,XY DSD and partial deletion of the short arm of chromosome 9 that presents motor development delay, and normal female genitalia (Figure 1A)

Summary

Introduction

Disorders of sex development (DSD) are congenital conditions which result in discordance between genetic, gonadal and phenotypic sex. Deletions and mutations of the SRY gene are present in 10-15% of DSD 46,XY female patients; deletions of 9p, which involve the DM domain, are associated with 46,XY DSD. Patients with this pathology present mental retardation and typical features of monosomy 9p syndrome [1,2,3,4]. We report a patient with 46,XY DSD and partial deletion of the short arm of chromosome 9 that presents motor development delay, and normal female genitalia (Figure 1A)

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