Abstract
Background and Aim:A metric that predicts the presence of cancer-related liver disease would allow early implementation of treatment. We compared the demographic and clinical characteristics of patients with no evidence of liver disease, with a cancer-associated liver disease, and with a liver disease not associated with cancer.Methods:Retrospective, hospital-based, cross-sectional study which reviewed the medical records of subjects who underwent health examinations at a Taiwanese hospital from 2000 to 2004 and who had normal levels of amino transaminases. Demographic and clinical data were analyzed by univariate and multivariate statistics.Results:A total of 2344 subjects had no evidence of liver disease (non-LD), and 1918 subjects had at least one liver disease (LD). The LD group was further divided into those with a cancer-associated liver disease (LD-1, n = 1632) and those with a liver disease not associated with cancer (LD-2, n = 286). Age, BMI, percentage of males, globulin:albumin ratio (G/A), percentage of patients with gallstones, AST, and ALT were significantly higher in the LD group. Univariate analysis showed that the G/A was significantly higher in the LD-2 group than the LD-1 group; multivariate analysis indicated that the G/A was not independently associated with liver disease, but that subjects who were older and had higher BMI were significantly more likely to have a cancer-associated liver disease. Conclusions: For patients with liver disease, a multivariate model can be used to distinguish those with a cancer-associated liver disease from those with a liver disease not associated with cancer.
Highlights
Liver disease includes many diverse conditions, diseases, and infections that affect the morphology and function of the liver [1]
Some liver diseases are associated with increased risk for cancer, including cirrhosis, in which the development of fibrotic tissues and scars leads to reduced liver function; fatty liver disease (FLD), which often occurs in patients with the metabolic syndrome and/ or those who consume excessive alcohol; and hepatoma, a tumor that is typically cancerous
All subjects were classified as having no evidence of liver disease, a liver disease that was associated with cancer (LD-1, including cancer-related FLD, cirrhosis, or hepatoma), or a liver disease not associated with cancer (LD-2, including cancer-unrelated FLD, cyst or hemangioma) based on symptoms and ultrasonography
Summary
Liver disease includes many diverse conditions, diseases, and infections that affect the morphology and function of the liver [1]. Some liver diseases are associated with increased risk for cancer, including cirrhosis, in which the development of fibrotic tissues and scars leads to reduced liver function; fatty liver disease (FLD), which often occurs in patients with the metabolic syndrome and/ or those who consume excessive alcohol; and hepatoma, a tumor that is typically cancerous. 2. LD-2, not cancer-related (n = 286): Fatty liver: n = 116 Liver cyst: n = 215 Hemangioma: n = 76. LD-2, not cancer-related (n = 286): Fatty liver: n = 116 Liver cyst: n = 215 Hemangioma: n = 76 In this retrospective study, we compared numerous demographic and clinical factors of patients with a cancer-associated liver disease and patients with liver diseases that are not associated with cancer
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