Abstract
Polyunsaturated fatty acid (PUFA) intake is generally associated with better renal function, while the association of monounsaturated fatty acids (MUFAs) remains unconfirmed. Mendelian randomization (MR) analysis was used to obtain unconfounded estimates of the causal association of dietary intake and genetically determined serum PUFA and MUFA levels with measures of renal function. Data from participants of the National Health and Nutrition Examination Surveys (NHANES) from 2005 to 2010 were used. Data from the largest genome-wide association studies (GWAS) on MUFAs, PUFAs, eGFR, and chronic kidney disease (CKD) were analysed for the entire sample. A total of 16,025 participants were included. eGFR improved across increasing quartiles of total PUFA intake from 86.3 ± 0.5 (Q1) to 96.2 ± 0.5 mL/min/1.73 m² (Q4), (p < 0.001). Conversely, there was no association between MUFA intake and measures of renal function (all p > 0.21). In multivariable models, the top quartile of PUFA intake had a 21% lower risk for CKD, but there was no significant association between CKD risk and MUFA intake. Genetically determined serum MUFA (heptadecenoate (17:1), myristoleic acid (14:1), and palmitoleic acid (16:1)) and PUFA (α-linolenic acid and eicosapentaenoic acid) concentrations had no significant association with eGFR and CKD risk. Additionally, no association was found in the analyses stratified by diabetes status. Higher dietary PUFA intake is associated with lower risk of CKD, while there was no association with serum levels of MUFAs or PUFAs. Additional studies including clinical trials are warranted.
Highlights
Licensee MDPI, Basel, Switzerland.Chronic kidney disease (CKD) is defined as significantly impaired kidney function, identified by a reduced glomerular filtration rate (GFR) or increased urinary albumin excretion that are confirmed on two or more occasions at least 3 months apart [1]
With regard to monounsaturated fatty acids (MUFAs) intake, in three different models with rangevaried confounders, we found no association between intake of MUFA and prevalent chronic kidney disease (CKD) (Table 3)
PUFAsintake, intake,along alongwith witha a InInthis set of genetic variants that have been demonstrated to be associated with four circulating set of genetic variants that have been demonstrated to be associated with four circulating serum MUFAs and polyunsaturated fatty acids (PUFA) in order to determine their association with renal function
Summary
Licensee MDPI, Basel, Switzerland.Chronic kidney disease (CKD) is defined as significantly impaired kidney function, identified by a reduced glomerular filtration rate (GFR) or increased urinary albumin excretion (albuminuria) that are confirmed on two or more occasions at least 3 months apart [1]. CKD is known to be associated with. Contribute to the disease burden of multiple comorbidities including diabetes [4–6], hypertension [7,8], obesity [9,10], and especially cardiovascular diseases [11–14], and as such, it is associated with a higher all-cause mortality [13]. Both low plasma concentrations and dietary intakes of n-3 and n-6 polyunsaturated fatty acids (PUFA) have previously been associated with impaired renal function [15–17], while a lower saturated fatty acid (SFA) intake has been associated with improved renal function [18]. The association between monounsaturated fatty acids (MUFA) and risk of CKD, remains poorly understood.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
