Association of dietary fiber and glycemic load with abnormal glucose metabolism

Abstract

Objective To investigate the status of dietary fiber(DF)and dietary glycemic load(GL)in middle-aged and elderly population, and to analyze the correlation of DF and GL with abnormal glucose metabolism. Methods Subjects aged 40-79 years came from Guangzhou community. Dietary nutrients intakes were assessed by continuous 24 hours review for 3 days. Correlation of abnormal glucose metabolism with GL and DF and their interaction were analyzed as quintiles of the distribution. Results Of 1 832 subjects, there were 990 subjects(54.0%)with normal glucose tolerance, 640(34.9%)with IGR, and 202(11.0%)newly-diagnosed diabetes mellitus(DM). Average DF intake of subjects was(11.5±4.5)g/d and average GL intake was(181.0±7.5)/d. Compared with the highest quintile group of total DF intake, the risk of abnormal glucose metabolism in the lowest quintile group was increased[OR=1.99, 95%CI(1.48, 2.67)], with increased IGR risk[OR=1.85, 95%CI(1.34, 2.57)] and DM risk[OR=2.36, 95%CI(1.50, 3.73)]. Compared with the lowest quintile group of GL intake, the risk of abnormal glucose metabolism in the highest quintile group was increased[OR=1.58, 95%CI(1.18, 2.13)], and with increased IGR risk[OR=1.75, 95%CI(1.26, 2.42)] and DM risk[OR=1.22, 95%CI(0.77, 1.94)]. The lowest quintile of DF and the highest quintile of GL was associated with the risk of increased abnormal glucose metabolism[OR=3.43, 95%CI(1.41, 8.36)]. Conclusion Abnormal glucose metabolism was negatively related with DF and positively related with GL. Key words: Dietary fiber; Glycemic load; Abnormal glucose metabolism; Diabetes mellitus; Impaired glucose regulation