Abstract
The objective of this study was to investigate relationship between the K232A mutation in the DGAT1 gene and the C963T mutation in the Leptin gene with reproduction traits. The study was conducted on 286 pure breed Holstein cows. In DGAT1 we found a favorable effect of AA genotype on age at the first calving (p˂0.15) and on conception rate after first service in heifers (p˂0.15). In the Leptin a positive effect of CC genotype on interval from calving to 1. service was observed (p˂0.05). A tendency for positive effect of CC genotype on age at the first service (p˂0.16) was observed as well. In another examined fertility traits we found no association with DGAT1 and Leptin genotypes. Present study brings a new information about studied SNP and such results may be used to assist genetic selection in dairy cattle.
Highlights
During last decades we can observe an increase in milk production which is often associated with decreased health and fertility due to its negative genetic correlation (Pryce et al, 2004)
The Leptin gene (LEP) was mapped to chromosome 4 and it consists of three exons
The C963T mutation was primarily studied for an association with energy status (Liefers et al, 2005) and reproduction traits (Liefers et al, 2005; Clempson et al, 2011), the C963T mutation seems to be very important in production traits like milk yield and milk content (Kadlecova et al, 2014)
Summary
During last decades we can observe an increase in milk production which is often associated with decreased health and fertility due to its negative genetic correlation (Pryce et al, 2004). Identification of markers involved to reproduction could help with managing decreasing trend in cattle reproduction. The Leptin gene (LEP) was mapped to chromosome 4 and it consists of three exons. 1366 mutations have been identified in the LEP gene (EMBL-EBI, 2016). The promoter region of LEP was firstly described by Liefers et al (2005). The C963T mutation was primarily studied for an association with energy status (Liefers et al, 2005) and reproduction traits (Liefers et al, 2005; Clempson et al, 2011), the C963T mutation seems to be very important in production traits like milk yield and milk content (Kadlecova et al, 2014)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
