Abstract
Objective:C1q/tumor necrosis factor-related protein-5 (CTRP5) is a novel peptide hormone involved in the metabolism of energy regulation. Polycystic ovary syndrome (PCOS), which is a reproductive and metabolic disorder, is associated with insulin resistance. The aim of the current study was to compare circulating levels of CTRP5 in women with and without PCOS and to investigate possible associations between CTRP5 and metabolic-hormonal parameters.Material and Methods:The present cross-sectional study contained 80 women with PCOS and 80 age and body mass index-matched women without PCOS. Circulating levels of CTRP5 were calculated using an enzyme-linked immunosorbent assay. We also measured hormonal and metabolic parameters.Results:Patients with PCOS had lower levels of circulating CTRP5 compared with women without PCOS (6.90±2.64 vs 11.73±3.66 ng/mL, p<0.001). CTRP5 was negatively correlated with insulin resistance, free-androgen index, and body mass index in both the PCOS and control groups. Moreover, patients with PCOS who had insulin resistance showed lower circulating CTRP5 levels compared with those without insulin resistance. In both the control and PCOS groups, overweight subjects had lower circulating levels of CTRP5 compared with participants of normal weight. Logistic regression analyses indicated that subjects in the lowest tertile for CTRP5 level had higher risk for PCOS compared with those in the highest tertile of CTRP5.Conclusion:Decreased circulating levels of CTRP5 were associated with higher risk of PCOS, as well as having metabolic disturbance among women with PCOS.
Highlights
Polycystic ovary syndrome (PCOS) is known as a common metabolic and reproductive disease in women of reproductive age, which is characterized by ovulatory dysfunction, clinical and/or laboratory hyperandrogenism, and polycystic ovaries
We demonstrated that C1q/tumor necrosis factor-related protein-5 (CTRP5) levels were in negatively correlated with waist circumference, body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR), free androgen index (FAI), and triglycerides, whereas high-density lipoprotein cholesterol (HDL-C) was positively correlated with CTRP5
CTRP5 is a newly defined adipokine, which is involved in energy metabolism; we tried to evaluate CTRP5 levels in women with PCOS
Summary
Polycystic ovary syndrome (PCOS) is known as a common metabolic and reproductive disease in women of reproductive age, which is characterized by ovulatory dysfunction, clinical and/or laboratory hyperandrogenism, and polycystic ovaries. PCOS is associated with low-grade chronic inflammation Both insulin resistance and low-grade inflammation induce hormonal and metabolic abnormalities in women with PCOS [1,4]. Changes in expression levels of various peptides in adipose tissue such as adiponectin in women with PCOS lead to hormonal and metabolic dysfunctions [5,6]. C1q/tumor necrosis factor-related protein-5 (CTRP5), a secreted peptide hormone and adiponectin paralog, is involved in energy metabolism, including glucose and lipid metabolism. Genetically CTRP5-deficient mice showed improved insulin action [12] In accordance with these results, patients with type 2 diabetes (T2DM) were revealed to have lower CTRP5 levels, and CTRP5 was negatively correlated with both body mass index (BMI), as well as insulin resistance [14]. We compared CTRP5 levels in women with PCOS and control participants without PCOS and investigated relationships between CTRP5 and hormonal or metabolic parameters
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