Association of CYP1A1, GSTM1 and GSTT1 gene polymorphisms with risk of prostate cancer in Algerian population

Somia Medjani,Djalila Chellat-Rezgoune,Noureddine Abadi,Mohammed Chidekh,Dalila Satta,Taher Kezai

doi:10.1186/s12301-020-00049-2

Somia Medjani, Djalila Chellat-Rezgoune + Show 4 more

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https://doi.org/10.1186/s12301-020-00049-2

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Abstract

BackgroundProstate cancer is the most common cancer in the world, and its etiology involves the interaction of genetic and environmental factors. Interindividual differences observed in the metabolism of xenobiotics may be due to polymorphisms of genes encoding the detoxification enzymes. This genetic variability seems to be associated with differences in susceptibility to certain types of cancers, including prostate cancer. Our study has been made in order to investigate a possible genetic predisposition to prostate cancer in an Algerian population, through the analysis of genetic polymorphisms of three enzymes metabolizing xenobiotics namely cytochrome P450 (CYP) 1A1, glutathione S-transferase mu 1 (GSTM1) and GST theta 1 (GSTT1).MethodsThe current case–control study included 101 prostate cancer patients and 101 healthy controls. Genotyping of CYP1A1 T3801C polymorphisms and GSTM1/GSTT-null was made, respectively, by PCR-RFLP and multiplex PCR.ResultsNo significantly positive associations were found for the CYP1A1 T3801C [p = 0.71, OR = 1.23 (0.56–2.72)] and GSTM1-null [p = 0.26, OR = 1.37 (0.76–2.4)] polymorphisms and prostate cancer susceptibility. However, we detect a highly significant association between GSTT1-null genotype [p = 0.03, OR = 2.03 (1.06–3.99)], GSTM1/GSTT1-double null genotype [p = 0.027, OR = 2.6; CI (1.07–6.5)] and prostate cancer risk. Furthermore, no statistically significant differences between the studied polymorphisms and tumor parameters (the Gleason score and clinical stages of aggressiveness) at diagnosis of PCa.ConclusionsThe risk of developing prostate cancer in Algeria does not appear to be associated with CYP1A1 T3801C genotypes and GSTM1-null, but GSTT1-null and GSTM1/GSTT1-double null genotypes increased the risk of prostate cancer.

Highlights

Prostate cancer (PCa) is considered as a major public health problem in the world because of its increased mortality and morbidity rates
There was no significant interaction between CYP1A1, glutathione S-transferase mu 1 (GSTM1), GSTT1genotypes and smoking
5 Discussion This paper reports for the first time in Algeria the relation between the genetic polymorphism of three enzymes metabolizing xenobiotics (CYP1A1, GSTM1, Glutathione S-transferase (GST) theta 1 (GSTT1))

Summary

Introduction

Prostate cancer (PCa) is considered as a major public health problem in the world because of its increased mortality and morbidity rates. Xenobiotic-metabolizing enzymes (XME), coded by a family of xenobiotic-metabolizing genes (XMG), have a major role in elimination of many xenobiotics or environmental chemical compounds from the body This mechanism of detoxification occurs in two phases [7]. Interindividual differences observed in the metabolism of xenobiotics may be due to polymorphisms of genes encoding the detoxification enzymes This genetic variability seems to be associated with differences in susceptibility to certain types of cancers, including prostate cancer. Our study has been made in order to investigate a possible genetic predisposition to prostate cancer in an Algerian population, through the analysis of genetic polymorphisms of three enzymes metabolizing xenobiotics namely cytochrome P450 (CYP) 1A1, glutathione S-transferase mu 1 (GSTM1) and GST theta 1 (GSTT1)

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