Abstract
To determine the impact of Kisspeptin on male reproductive axis in a selected urban population. The cross-sectional study was conducted at the Sindh Institute of Reproductive Medicine in collaboration with Aga Khan University, Karachi, from July, 2017, to February, 2018, and comprised infertile males with abnormal sperm parameters who were placed in Group A and fertile males with normal sperm parameters placed in Group B. Serum samples were estimated for Kisspeptin, follicle stimulating hormone, luteinizing hormone, testosterone and sex hormone-binding globulin using enzyme-linked immunosorbent assay. Data was analysed using SPSS 22. Of the 313 male subjects, 178(57%) were in Group A and 135(43%) in Group B. Median Kisspeptin levels were higher among fertile males compared to infertile males (p<0.001). Mean follicle stimulating hormone, luteinizing hormone and testosterone values were higher among the fertile males (p<0.001). There was significant interaction between follicle stimulating hormone and testosterone (p<0.1). Fertility in males depended on optimal secretion of Kisspeptin which exert edits effect on hypothalamic pituitary gonadal axis to increase male reproductive hormone production.
Highlights
Infertility can be defined as the inability of a sexually active, non-contracepting couple to achieve spontaneous pregnancy after one year.[1]
Studies carried out to determine the role of KP in the regulation of the reproductive axis have documented an increase in oocyte maturity and clinical pregnancy rates of females after intracytoplasmic sperm injection (ICSI), especially in cases of unexplained infertility.[6,7]
The mean age of the fertile participants was higher, but infertile males had a higher BMI and Body fat percentage (BF%) value compared to the fertile group (p
Summary
Infertility can be defined as the inability of a sexually active, non-contracepting couple to achieve spontaneous pregnancy after one year.[1] It is a global problem that entails serious sexual and social consequences that strain the health sector and society as a whole.[2] According to Agarwal et al, male factors account for 20-70% of infertility problems faced by the commonly quoted 15% of couples worldwide.[3] This may be due to congenital or acquired urogenital problems, abnormalities, genetic predisposition, immune system factor disorders of the immune system, infections, malignancies and/or endocrine malfunction, but 30% of the time, male infertility presents idiopathically.[4]. KISS1 acts on KISS1 receptors on gonadotrophic-releasing hormone
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