Abstract
Irisin is a myokine with potential anti-obesity properties that has been suggested to increase energy expenditure in obese patients. However, there is limited clinical information on the biology of irisin in humans, especially in morbidly obese patients undergoing bariatric surgery. We aimed to assess the association of circulating irisin concentrations with weight loss in obese patients undergoing bariatric surgery. This was a pilot, single-centre, longitudinal observational study. We recruited 25 morbidly obese subjects who underwent Roux-en-Y gastric bypass surgery (RYGBP), and blood samples from 12 patients were taken to measure serum irisin concentrations before, and one and nine months after surgery. Their clinical characteristics were measured for one year. The preoperative serum irisin concentration (mean 1.01 ± 0.23 μg/mL, range 0.73–1.49) changed bidirectionally one month after RYGBP. The mean concentration at nine months was 1.11 ± 0.15 μg/mL (range 0.92–1.35). Eight patients had elevated irisin levels compared with their preoperative values, but four did not. Elevations of irisin levels nine months, but not one month, after surgery, were associated with lower preoperative levels (p = 0.016) and worse weight reduction rates (p = 0.006 for the percentage excess weight loss and p = 0.032 for changes in body mass index). The preoperative serum irisin concentrations were significantly correlated with the percentage of excess weight loss for one year (R2 = 0.612; p = 0.04) in our study. Our results suggest that preoperative circulating irisin concentrations may be at least in part associated with a weight loss effect of bariatric surgery in morbidly obese patients. Further large-scale clinical studies are needed to ratify these findings.
Highlights
Obesity is one of the most concerning health problems in the world [1]
The eligible population of this prospective cohort study was obese patients who agreed to participate in the research and who underwent standard laparoscopic Roux-en-Y gastric bypass surgery (RYGBP) [29] from July 2011 to September 2013 at the Obesity Center, Inha University Hospital in Incheon, South Korea
We decided to measure the irisin concentrations on, before, and at one and nine months after surgery because we hypothesized that signals from muscles could and at one and nine months after surgery because we hypothesized that signals from muscles could contribute to the weight reduction effects of bariatric surgery and that surgery could have an influence contribute to the weight reduction effects of bariatric surgery and that surgery could have an on the signaling of muscles
Summary
Obesity is one of the most concerning health problems in the world [1]. In addition to causing type 2 diabetes mellitus, it triggers certain forms of cancer, respiratory complications, and cardiovascular diseases, which lead to high rates of mortality and morbidity [2]. Obesity is a state of excess adiposity coupled with adiposopathy, which provokes chronic inflammation and dysregulation of energy homeostasis [3]. Res. Public Health 2019, 16, 660; doi:10.3390/ijerph16040660 www.mdpi.com/journal/ijerph
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