Association of Circulating COMP and YKL-40 as Markers of Metabolic Changes of Cartilage with Adipocytokines in Juvenile Idiopathic Arthritis.

Katarzyna Winsz-Szczotka,Klaudia Dąbkowska,Kornelia Kuźnik-Trocha,Krystyna Olczyk,Magdalena Wojdas,Anna Gruenpeter

doi:10.3390/metabo10020061

Katarzyna Winsz-Szczotka, Klaudia Dąbkowska + Show 4 more

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https://doi.org/10.3390/metabo10020061

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Journal: Metabolites	Publication Date: Feb 10, 2020
Citations: 4	License type: CC BY 4.0

Affiliation: Medical University of Silesia

Abstract

The aim of this study was to evaluate the association of circulating cartilage oligomeric matrix protein (COMP) and human cartilage glycoprotein-39 (YKL-40) as markers of metabolic changes of cartilage, with leptin, adiponectin, and resistin in juvenile idiopathic arthritis (JIA) patients before and after treatment. A significant decrease of COMP and an increase of YKL-4 were found in blood of untreated patients. JIA treatment leading to clinical improvement resulted in normalization of COMP levels only. Concentrations of both markers in treated patients, while showing no clinical improvement, differed from those in controls and patients with remission. The leptin level decreased (p < 0.05) in untreated patients; however, concentrations of adiponectin and resistin increased (p < 0.05) as compared to controls. JIA treatment resulted in normalization of adipocytokine levels in remissive patients but not those with active JIA. Untreated patients showed a correlation between COMP and leptin, adiponectin, and body mass index (BMI) and between YKL-40 and leptin, adiponectin, BMI, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). In inactive JIA, a correlation between YKL-40 and leptin was shown. Treated patients with an active JIA demonstrated a correlation between COMP and adiponectin and between YKL-40 and leptin, adiponectin, BMI, CRP, and ESR. The results of this work indicate that leptin and adiponectin but not resistin may be involved in the development and progression of joint dysfunction in JIA. Additionally, we suggest that YKL-40 may be a useful biomarker of disease activity and may be used to assess treatment towards remission, as compared to COMP.

Highlights

Juvenile idiopathic arthritis (JIA) is the most prevalent inflammatory disease of connective tissue in pediatric patients [1,2,3]
Among extracellular matrix (ECM) components, which are indicators of the cartilage breakdown, there are listed components synthesized by chondrocytes, i.e., cartilage oligomeric matrix protein (COMP) as well as human cartilage glycoprotein 39 (YKL-40), that are so far not evaluated in JIA patients
We have evaluated the interactions between COMP, YKL-40, and the body mass index (BMI)

Summary

Introduction

Juvenile idiopathic arthritis (JIA) is the most prevalent inflammatory disease of connective tissue in pediatric patients [1,2,3]. The progressive wear of articular cartilage in the course of JIA results in imbalance between biological resistance of the cartilage, its function, and the contact force. Such disorders are attributed to changes in homeostasis of the extracellular matrix (ECM) components of cartilage. Proteoglycans, including aggrecan, decorin, or biglycan, play a special role, maintaining the mechanical and immune properties of cartilage [1,2,3,4,5]. Among ECM components, which are indicators of the cartilage breakdown, there are listed components synthesized by chondrocytes, i.e., cartilage oligomeric matrix protein (COMP) as well as human cartilage glycoprotein 39 (YKL-40), that are so far not evaluated in JIA patients. The first one is a non-collagenous glycoprotein, binding to aggrecan; fibronectin; and collagen types I, II, and IX, which seem to play a role in the structure of fibrils and in maintenance of the collagen network [9,10]

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