Association of circulating CEACAM1 levels and insulin sensitivity in gestational diabetes mellitus

Yiming Wu,Lingfei Zhu,Zhen Yang,Li Qin,Qing Su

doi:10.1186/s12902-020-00550-3

Yiming Wu, Lingfei Zhu + Show 3 more

Open Access

https://doi.org/10.1186/s12902-020-00550-3

Copy DOI

Abstract

BackgroundThe aim of this study was to estimate the levels of circulating carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in subjects with gestational diabetes mellitus (GDM) and investigate the relationships between CEACAM1 and GDM.MethodsCirculating CEACAM1 levels were measured by ELISA kit in 70 women with GDM and 70 normal glucose tolerance (NGT) pregnant women. Blood samples were collected to detect fasting plasma glucose (FPG), fasting insulin (FINS) and glycosylated hemoglobin (HbA1c) levels in all participants. Insulin sensitivity index (ISOGTT) was calculated to assess insulin sensitivity. Correlation analysis was performed between serum CEACAM1 levels and other parameters.ResultsCirculating CEACAM1 levels were higher in the GDM group than that in the NGT pregnant group, however, the difference showed no statistical significance (1889.82 ± 616.14 vs 1758.92 ± 433.15 pg/ml, p > 0.05). In GDM group, CEACAM1 was positively correlated with ISOGTT (R = 0.39, P = 0.001), while negatively with 1 h post-meal plasma insulin level (1hPINS) (R = -0.32, P = 0.008), 2 h post-meal plasma insulin level (2hPINS) (R = -0.33, P = 0.006) and area under curve of insulin (AUCI) (R = -0.36, P = 0.002) when adjusting for maternal age and gestational age.ConclusionsThe present study showed that circulating CEACAM1 levels did not differ in both GDM and NGT groups. However, we found a significant positively correlation between CEACAM1 and insulin sensitivity in the GDM group.

Highlights

The aim of this study was to estimate the levels of circulating carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in subjects with gestational diabetes mellitus (GDM) and investigate the relationships between CEACAM1 and GDM
CEACAM1 is a substrate of the insulin receptor in liver, and it is phosphorylated in response to insulin in hepatocytes and induces insulin clearance by increasing receptor-mediated endocytosis and degradation [11,12,13]
Clinical and biochemical characteristics of the studied groups As shown in Table 1, compared with normal glucose tolerance (NGT) group, the GDM group had higher maternal age, fasting plasma glucose (FPG), 1hPG, 2hPG, fasting insulin (FINS), 1 h post-meal plasma insulin level (1hPINS), 2 h post-meal plasma insulin level (2hPINS), HOMA-IR, Area under curve of glucose (AUCG), area under curve of insulin (AUCI), neonatal weight and the percentages of positive family history of diabetes(all P < 0.05), while ISOGTT, △I60/△G60 of GDM group were significantly lower than the NGT group

Summary

Introduction

The aim of this study was to estimate the levels of circulating carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in subjects with gestational diabetes mellitus (GDM) and investigate the relationships between CEACAM1 and GDM. The prevalence of GDM has been increasing worldwide, especially in some developing countries [2]. Due to different diagnostic tests, Recently, Carcinoembryonic antigen-related cell adhesion molecule one (CEACAM1) has been suggested as a potential regulatory molecules in the pathology of IR. CEACAM1 known as CD66a, BGP, belongs to the carcinoembryonic antigen (CEA) family [8]. It expresses highly in liver, but not in classical insulin target peripheral tissues such as white adipose tissue and skeletal muscle [9]. We hypothesize that CEACAM1 may play a protective role in the occurrence and development of GDM

Objectives

Methods

Results

Discussion

Conclusion