Association of Chorioamnionitis with Neonatal Sepsis and Mortality Rate Among Preterm Infants: A Meta-Analysis

Abstract

horioamnionitis is an intra-amnion infection caused by various pathogens and increases the risk of preterm delivery. This study aims to analyze the association of chorioamnionitis with the incidence of neonatal sepsis and mortality rate among preterm infants. This systematic review and meta-analysis was conducted based on PRISMA guideline. All studies which evaluated chorioamnionitis with the incidence of neonatal sepsis and mortality rate among preterm infants were included in this study. We limited our search to 2001-2020. A total of 34 articles were screened. Nine cohorts were included according to inclusion criteria. Based on statistical analysis, chorioamnionitis was associated with the incidence of early-onset sepsis (OR=3.45; 95%CI=2.02-5.89; p < 0.00001). Chorioamnionitis had a protective effect toward late-onset sepsis (OR=0.82; 95%CI=0.71-0.93; p=0.003) and not associated with mortality rate among preterm infants (OR 0.75; 95%CI=0.54-1.04; p=0.09). Chorioamnionitis was associated with higher risks of early-onset sepsis and lower risks of late-onset sepsis. However, the mortality rate among preterm infants with early-onset sepsis was not associated with chorioamnionitis.