Association of chemerin levels in synovial fluid with the severity of knee osteoarthritis

Abstract

Context: Chemerin has been implicated to be correlated with inflammation.Objective: This study aims to determine the association of chemerin levels in serum and synovial fluid (SF) with the disease severity of patients with knee Osteoarthritis (OA).Methods: 124 patients with knee OA and 76 healthy controls were enrolled in this study.Results: Chemerin levels in serum were significant higher with regard to paired SF. Chemerin levles in SF of knee OA patients were correlated with disease severity evaluated by KL grading criteria.Conclusion: Chemerin levels may be involved in the pathophysiology of the development and progression of OA.