Association of Changes of Thyroid Hormone Levels With Brominated Flame Retarded Exposure Around E-waste Dismantling Site

Abstract

PP-29-109 Background/Aims: Brominated flame retarded (BFR) released from e-waste activity might affect the health of local people. Assessing the effect of e-waste exposure via recycling, and dismantling and changes of thyroid hormone levels is an area of ongoing research. Methods: The processing of e-waste recycling was investigated. A total of 236 occupational exposure people and 89 nonoccupational exposure people from e-waste recycling sites were surveyed, and their thyroid hormone levels (T3 and T4), free thyroid hormones (fT3 and fT4), and thyroid stimulating hormone were assayed. The level of polybrominated diphenyl ethers congeners and Polybrominated biphenyl congeners in serum was determined here. Linear regression model was taken to analyze the relations between thyroid hormone levels and BFRs concentrations. Results: Lower level of T3 in exposure groups were observed (P < 0.01). BDE205 with T4 positively varied were confirmed by linear regression model (unstandardized regression coefficient, beta = 0.25, ρ = 0.001) and a weaker positively trend in BDE126 and T4 was found. Conclusion: BFRs exposure may contribute to the changes of thyroid hormone levels.