Abstract
Background: Post-stroke depression (PSD) is one of the most common complications after stroke, which seriously affects patients' recovery outcome. Although vascular depression has been extensively studied, the relationship between cerebral artery stenosis and PSD has not been clarified so far.Methods: Two hundred ninety-eight patients with ischemic stroke (72 women, 226 men) with computed tomography angiography (CTA) or magnetic resonance angiography (MRA) were included in this study. Cerebral artery stenosis ≥50% was used as the cut-off value. The DSM-V diagnostic criteria of PSD was met and the 17-item Hamilton Rating Scale for Depression (HAMD-17) score over 7 at discharge and 3 months after stroke onset was regarded as the primary outcome. The χ2-test, Mann-Whitney U-test, and t-test were used to check for statistical significance.Results: At discharge, Barthel index (p < 0.001), left middle cerebral artery stenosis (p = 0.019), drinking history (p = 0.048), basilar artery stenosis (p = 0.037) were significantly associated with PSD. At 3 months after ischemic stroke onset, Barthel index (p = 0.011), left middle cerebral artery stenosis (p = 0.012), female gender (p = 0.001) were significantly associated with PSD.Conclusions: The findings demonstrated that left middle cerebral artery and basilar artery stenosis are associated with PSD. It was suggested that cerebral artery stenosis was a risk factor of PSD and should be recognized and intervened early.Registration Number: ChiCTR-ROC-17013993.
Highlights
Post-stroke depression (PSD), characterized by obvious reduction in mood and physical vitality [1,2,3], is a common psychiatric comorbidity after stroke
The main purpose of this study was to evaluate whether cerebral artery stenosis in patients with ischemic stroke measured by computed tomography angiography (CTA) or magnetic resonance angiography (MRA) was related to PSD at discharge and 3 months after the attack
The age of the enrolled patients was 57.42 ± 10.15, 75.84% of patients were male and 24.16% of patients were female, 40.27% patients had smoking history, 16.44% patients had drinking history, 54.36% patients had a history of hypertension, and 24.83% patients had a history of diabetes mellitus
Summary
Post-stroke depression (PSD), characterized by obvious reduction in mood and physical vitality [1,2,3], is a common psychiatric comorbidity after stroke. Studies have shown that the hemodynamics changes of the middle cerebral artery are related to the onset of depression in the elderly [13]. Animal studies have shown that depression-like behavior in rats was related to cerebral hypoperfusion [14]. The patient with cerebral artery stenosis may have experienced corresponding cerebral hypoperfusion for a long time before the onset of ischemic stroke. It has not been studied whether depression after ischemic stroke was related to cerebral artery stenosis. Vascular depression has been extensively studied, the relationship between cerebral artery stenosis and PSD has not been clarified so far
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