Abstract
e20504 Background: New prognostic markers are being searched to determine the value of adjuvant and/or palliative treatment in soft tissue sarcomas (STS). Several studies have shown, that CD44 expression is associated with a better outcome in certain cancers, such as bladder tumors. The aim of this study was to evaluate the expression of CD44 in STS of the adult and to determine whether CD44 expression correlates with the clinical outcome Methods: We examined the clinical outcome of 34 adult MFH patients (19 males and 15 females, average age 62 years, median 63 years, ranged from 38 to 88 years) who underwent curative treatment for STS. The majority of patients received adjuvant radiotherapy (n = 25). No patient received initial adjuvant chemotherapy. The expressions of CD44, CD44 isoforms and the reference genes beta-actin and beta-microglobulin were analyzed by quantitative real-time PCR. For relative quantification and to normalize the amount of the CD44 product and the CD44 isoform products, the delta...
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