Association of CD14 genetic variants and circulating level with systemic lupus erythematosus risk in Egyptian children and adolescents.

Abstract

Aim: To demonstrate whether sCD14 and CD14 (rs2569190 A/G and rs2569191 C/T) genetic variants are associated with systemic lupus erythematosus (SLE) risk, for the first time, in Egyptian pediatrics and adolescents. Materials & methods: sCD14 concentrations were determined in plasma of 95 SLE cases and 98 healthy controls using ELISA assay. Genotyping was performed using TaqMan technology. Results: sCD14 levels were elevated in SLE. Individuals with T, CTand TTgenotypes in rs2569191 were of significant risk (odds ratio =1.471-2.035, 95% CI=1.138-3.471) and those with combined CT+TTand haplotype GTwere of higher risk of SLE (odds ratio =1.660-1.758, 95% CI=1.003-3.106, p<0.05). sCD14 levels and CD14 polymorphism were not correlated with SLE clinical and laboratory features. Conclusion: In SLE, sCD14 levels are associated with rs2569190 A/G. Genotype CT+TTin rs2569191 C/T and haplotype GTare associated with SLE risk in Egyptian pediatric and adolescents.