Association of carotid disease with vasoactivators in hypertension patients

Abstract

Discuss the influence of the change of vasoactivors such as nitric oxide and endothelin on the carotid disease when the patients got the hypertension therapy. After the carotid ultrosound examination, we divide the 120 patients into 4 groups according to their carotid disease. Normal group(30 cases), endothelial thickness group(30 cases), hard plaque group(30 cases) and soft plaque group(30 cases). Measure the concentration of nitric oxide and endothelin in serum of hypertension patients before and after therapy. Compared with non-plaque group, soft plaque group had lower levels of nitric oxide. The difference was notability (P<0.05). So was the hard plaque group (P<0.05). After our therapy, the number of reach aim blood pressure: (1)normal group is 23, (2)endothelia thickness is 25,(3)hard plaque is 28, (4)soft plaque is 21. The number of stroke after 2 years: (1)normal group is 2, (2)endothelia thickness is 3,(3) hard plaque is 2, (4)soft plaque is 7. We use long-time calcium antagonist to treat those patients. But we found no difference on stroke between the team up to scrath and the team no up to scrath. The difference is evidence between the form of carotid plaque and the endodermis trauma of hypertension. So if we want to give the best protest to the vascular, we must therapy his hypertension first. (See Table) The change of vasoactivators before and after therapy #P < 0.05:P < 0.01 compared with post-treament. The change of vasoactivators before and after therapy #P < 0.05:P < 0.01 compared with post-treament.