Abstract
Metabolic syndrome (MetS) is complex and determined by the interaction between genetic and environmental factors and their influence on obesity, insulin resistance, and related traits associated with diabetes and cardiovascular disease risk. Some dynamic markers, including adiponectin (ADIPOQ), brain-derived neurotrophic factor (BDNF), and lipoprotein lipase (LPL), are implicated in MetS; however, the influence of their genetic variants on MetS susceptibility varies in racial and ethnic groups. We investigated the association of single nucleotide polymorphism (SNP)-SNP interactions among nine SNPs in six genes with MetS’s genetic predisposition in Mongolian subjects. A total of 160 patients with MetS for the case group and 144 healthy individuals for the control group were selected to participate in this study. Regression analysis of individual SNPs showed that the ADIPOQ + 45GG (odds ratio (OR) = 2.09, p = 0.011) and P+P+ of LPL PvuII (OR = 2.10, p = 0.038) carriers had an increased risk of MetS. Conversely, G allele of LPL S447X (OR = 0.45, p = 0.036) and PGC-1α 482Ser (OR = 0.26, p = 0.001) allele were estimated as protective factors, respectively. Moreover, a haplotype containing the G-P+-G combination was related to MetS. Significant loci were also related to body mass index (BMI), systolic blood pressure (SBP), serum high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), and fasting blood glucose (FBG), adipokines, and insulin as well as insulin resistance (p < 0.05). Our results confirm that ADIPOQ + 45T > G, LPL PvII, and PGC-1α Gly482Ser loci are associated with MetS in Mongolian subjects.
Highlights
Metabolic syndrome MetS is a substantial global public health problem and concern because of its high prevalence (20–25% of the world’s adult population) and linked to more severe pathologies [1].Those with MetS are at a three-fold increased risk of developing cardiovascular diseases (CVDs) and five-fold increased risk of type 2 diabetes mellitus (T2DM) [2]
systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels were higher in patients with MetS than the control group (p < 0.001)
Our results suggest that the high-density lipoprotein cholesterol (HDL-C) and adiponectin levels were reduced more in ADIPOQ + 45T > G carriers (TG + GG) than those non-carriers (TT) in the dominant model (p = 0.032, p = 0.027, respectively)
Summary
Metabolic syndrome MetS is a substantial global public health problem and concern because of its high prevalence (20–25% of the world’s adult population) and linked to more severe pathologies [1]. Those with MetS are at a three-fold increased risk of developing cardiovascular diseases (CVDs) and five-fold increased risk of type 2 diabetes mellitus (T2DM) [2]. According to the IDF criteria, by 2015, the prevalence of MetS was estimated to occur in 32.7% in the general Mongolian population: socio-environmental factors including moderate-to-high alcohol consumption in men and widowed status in women are significantly associated with MetS [8]
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