Abstract
Background and Aim:Puerperal diseases influence fertility and should be diagnosed as soon as possible. This study aimed to evaluate the applicability of serum concentrations of substance P (SP), vasoactive intestinal polypeptide (VIP), and interleukin (IL)1β in the early diagnosis of uterine involution disturbances.Materials and Methods:Blood serum samples of 86 dairy cows from six different farms were harvested within the first 20 days after calving from cows with uterine involution disturbances and healthy controls, respectively. Serum concentrations for SP, VIP, and IL-1β were determined using commercially available ELISA test kits. Statistical analyses included timely changes in blood serum levels and group comparisons of healthy cows and cows with uterine disease.Results:SP concentrations increased significantly within 20 days after calving (p<0.04) with no significant difference observed between the groups. Moreover, no significant differences were found between VIP and log IL-1β.Conclusion:Results showed that none of the examined serum parameters seems suitable as indicator of uterine involution disorders. Due to the timely changes in serum concentrations of SP after calving, a correlation to diseases might not be precluded. Further research is needed as regards the establishment of normative values concerning this parameter.
Highlights
Postpartum uterine diseases result in infertility or subfertility and have high economic significance [1]
No significant differences were found between vasoactive intestinal polypeptide (VIP) and log IL-1β
Equivalent findings were obtained for log IL-1β values, with no statistically significant differences found in the timely course (p=0.166) nor within the group comparison (p=0.296; Figure-3)
Summary
Postpartum uterine diseases result in infertility or subfertility and have high economic significance [1]. A literature-based calculation of the direct costs of treatment reduced milk yield and subfertility associated with uterine disease revealed economic losses of up to £ 16 million/year in the UK [1]. Several diagnostic possibilities have been developed and validated [2]. Among these traditional diagnostic measures are the transrectal palpation of the uterus, ultrasonography, and vaginal discharge evaluation [2]. This study aimed to evaluate the applicability of serum concentrations of substance P (SP), vasoactive intestinal polypeptide (VIP), and interleukin (IL)1β in the early diagnosis of uterine involution disturbances
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