Abstract
Obesity is one of the major risk factors of cancer. However, how body mass index (BMI) influences the prognosis of renal cell cancer (RCC) patient is unclear. In this work, we have performed a meta-analysis to elucidate the role of abnormal weight in RCC mortality and postoperative survival. Articles related to BMI and RCC mortality as well as postoperative survival has been identified by searching PUBMED and ENBASE. Totally, 19 articles have been selected for this meta-analysis, 5 articles for RCC mortality and 14 for postoperative survival. Compared to normal weight, the estimated relative risks of RCC mortality are 0.71 (95% CI: 0.34–1.49), 1.19 (95% CI: 1.05–1.35) and 1.71 (95% CI: 1.27–2.00) respectively for the underweight, overweight and obesity patients. The risk of RCC mortality increase 5% for each 1 kg/m2 increment of BMI. However, the estimated hazard ratios of cancer specific postoperative survival are 2.62 (95% CI: 1.67–4.11), 0.72 (95% CI: 0.63–0.83) and 0.66 (95% CI: 0.49–0.89) respectively for underweight, overweight and obesity RCC patients. The risk of hazard ratio decrease 5% for each 1 kg/m2 increment of BMI. In addition, the hazard ratios of postoperative overall survival show a similar tendency. These results indicate an opposite association of BMI with mortality and postoperative survival in renal cell cancer patients.
Highlights
Cancer is one of the major causes of death in the world and an estimated 12.7 million new cancer cases occur annually, of which approximately 271,000 is new cases of kidney cancer [1]
The hazard ratios of postoperative overall survival show a similar tendency. These results indicate an opposite association of body mass index (BMI) with mortality and postoperative survival in renal cell cancer patients
19 articles were included for this meta-analysis, of which, 5 for renal cell cancer (RCC) mortality [21,22,23,24,25], and 14 for RCC postoperative survival [26,27,28,29,30,31,32,33,34,35,36,37,38,39]
Summary
Cancer is one of the major causes of death in the world and an estimated 12.7 million new cancer cases occur annually, of which approximately 271,000 is new cases of kidney cancer [1]. Renal cell carcinoma (RCC), accounting for 2%-3% of all adult malignancies, is the most common kidney malignancy [2]. Hypertension and smoking are known risk factors of RCC [4,5,6,7,8,9,10]. Increased BMI was reported to be associated with high RCC incidence [11,12,13] both in men and women [14], extreme obesity didn’t predict poor cancer outcomes after surgery in RCC patients [15], which indicated that the association between BMI and RCC prognosis is controversial. We performed a meta-analysis to explore the relationship between BMI and RCC mortality as well as postoperative survival
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