Abstract
BackgroundObesity might be associated with disturbance of cannulation in situation of extracorporeal cardiopulmonary resuscitation (ECPR). However, limited data are available on obesity in the setting of ECPR. Therefore, we investigated the association between body mass index (BMI) and clinical outcome in patients underwent ECPR.MethodsFrom January 2004 to December 2013, in-hospital cardiac arrest patients who had ECPR were enrolled from a single-center registry. We divided patients into four group according to BMI defined with the WHO classification (underweight, BMI < 18.5, n = 14; normal weight, BMI = 18.5–24.9, n = 118; overweight, BMI = 25.0–29.9, n = 53; obese, BMI ≥ 30, n = 15). The primary outcome was survival to hospital discharge.ResultsAnalysis was carried out for a total of 200 adult patients (39.5% females). Their median BMI was 23.20 (interquartile range, 20.93–25.80). The rate of survival to hospital discharge was 31.0%. There was no significant difference in survival to hospital discharge among the four groups (underweight, 35.7%; normal, 31.4%; overweight, 30.2%; obese, 26.7%, p = 0.958). Neurologic outcomes (p = 0.85) and procedural complications (p = 0.40) were not significantly different among the four groups either. SOFA score, initial arrest rhythm, and CPR to extracorporeal membrane oxygenation (ECMO) pump on time were significant predictors for survival to discharge, but not BMI.ConclusionBMI was not associated with in-hospital mortality who underwent ECPR. Neurologic outcomes at discharge or procedural complications following ECPR were not related with BMI either.
Highlights
Obesity has been implicated as one of the major risk factors for cardiovascular disease and congestive heart failure (HF) [1]
body mass index (BMI) was not associated with in-hospital mortality who underwent extracorporeal cardiopulmonary resuscitation (ECPR)
Neurologic outcomes at discharge or procedural complications following ECPR were not related with BMI either
Summary
Obesity has been implicated as one of the major risk factors for cardiovascular disease and congestive heart failure (HF) [1]. In cases of cardiac arrest, relationship with body mass index (BMI) and mortality is not clearly defined. Some studies suggest that increased BMI is positive factor on survival [4,5,6], while recent data suggest that obesity is related with higher mortality [7]. Chen et al [10,11] have reported that extracorporeal cardiopulmonary resuscitation (ECPR) is superior to conventional cardiopulmonary resuscitation (CPR) for in-hospital cardiac arrest patients. The objective of this study was to assess the association between body mass index (BMI) and clinical outcomes after in-hospital cardiac arrest following ECPR. We investigated the association between body mass index (BMI) and clinical outcome in patients underwent ECPR.
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