Abstract
Epidemiological studies have shown an etiological link between body mass index (BMI) and cancer risk, but evidence supporting these observations is limited. This study aimed to investigate potential associations of BMI with chromosome damage levels and lung cancer risk. First, we recruited 1333 male workers from a coke-oven plant to examine their chromosome damage levels; and then, a cohort study of 12 052 males was used to investigate the association of BMI with lung cancer incidence. We further carried out a meta-analysis for BMI and male lung cancer risk based on cohort studies. We found that men workers with excess body weight (BMI ≥ 25 kg/m2) had lower levels of MN frequencies than men with normal-weight (BMI: 18.5–24.9). Our cohort study indicated that, the relative risk (RR) for men with BMI ≥ 25 to develop lung cancer was 35% lower than RR for normal-weight men. Further meta-analysis showed that, compared to normal-weight men, men with BMI ≥ 25 had decreased risk of lung cancer among both the East-Asians and others populations. These results indicate that men with excess body weight had significant decreased chromosome damage levels and lower risk of lung cancer than those with normal-weight. However, further biological researches were needed to validate these associations.
Highlights
Epidemiological studies have shown an etiological link between body mass index (BMI) and cancer risk, but evidence supporting these observations is limited
Heterogeneity was not observed in overall analysis and subgroup analyses (Table 5). To our knowledge, this is the first study enrolling a large healthy occupational cohort whose findings indicated that men with excess body weight have significant low chromosomal damage levels when compared with normal-weight men
A new cohort study (DFTJ cohort) with 12 052 males was conducted in addition to metaanalysis of 12 previously published cohort studies to assess the associations between BMI and lung cancer incidence for male subjects
Summary
Epidemiological studies have shown an etiological link between body mass index (BMI) and cancer risk, but evidence supporting these observations is limited. One cohort study that had a mean follow-up of 5.4 years, showed that increased body mass index (BMI) is positively associated with increase on incidence of endometrial cancer, kidney cancer, and ovarian cancer[5] It was established through meta-analyses that the risks of pancreatic cancer, gallbladder cancer, and liver cancer were significantly higher among over-weight and/or obesity individuals than individuals with normalweight[6,7,8]. We hypothesized that excess body-weight may affect individual’s susceptibility to environmental genotoxicants and predisposition to cancer risk To investigate this association of BMI with chromosome damage levels, 1333 male workers from a coke-oven plant were recruited for the study. We conducted a prospective cohort study and a meta-analysis to investigate the association of BMI with lung cancer incidence among male populations
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