Abstract
BackgroundMost studies have suggested that elevated body mass index (BMI) was associated with the risk of death from all cause and from specific causes. However, there was little evidence illustrating the effect of BMI on the mortality in elderly hypertensive patients in Chinese population.MethodsThe information of 10,957 hypertensive patients at baseline not less than 60 years were from Xinzhuang, a town in Minhang district of Shanghai, was extracted from the Electronic Health Record (EHR) system. All study participants were divided into eight categories of baseline BMI (with cut-points at 18, 20, 22, 24, 26, 28 and 30 kg/m2). Relative hazard ratio of death from all cause, cardiovascular and non-cardiovascular cause by baseline BMI groups were calculated, standardized for sex, age, smoking, drinking, physical activity, systolic blood pressure, history of cardiovascular disorders, serum lipid disturbance, diabetes mellitus and antihypertensive drug treatment.ResultsDuring follow up (median: 3.7 years), 561 deaths occurred. Underweight (BMI<18 kg/m2) was associated with significantly increased mortality from all cause mortality (OR: 2.00; 95% CI: 1.43–2.79) and non cardiovascular mortality (OR: 2.76; 95% CI: 1.87–4.07), but not with cardiovascular mortality. For the cause specific analysis, the underweight was associated significantly with neoplasms (OR: 2.15; 95% CI: 1.16–4.00) and respiratory disorders (OR: 3.41; 95% CI: 1.64–7.06). The results for total mortality and specific cause mortality were not influenced by sex, age and smoking status.ConclusionOur study revealed an association between underweight and increased mortality from non-cardiovascular disorders in elderly hypertensive patients in Chinese community. Overweight and obesity were not associated with all cause or cause specific death.
Highlights
The prevalence of hypertension in China keeps increasing, until 2010, more than 200 million people suffer high blood pressure and it has become the leading preventable cause of death among adults 40 years of age and older [1]
To investigate the overall and specific risk of death associated with body weight in elderly hypertensive patients, we examined the association between body mass index (BMI) and cause specific death rates in a hypertension management database derived from electronic health records in Chinese community hospitals
The results indicated that underweight was associated with excess death from neoplasms (HR: 2.15; 95% confidence intervals (CIs): 1.16–4.00) and respiratory disorders (HR: 3.41; 95% CI: 1.64–7.06)
Summary
The prevalence of hypertension in China keeps increasing, until 2010, more than 200 million people suffer high blood pressure and it has become the leading preventable cause of death among adults 40 years of age and older [1]. There is long-standing disagreement regarding the effect of age on the association between underweight and all-cause mortality[8,9,10,11,12,13,14,15]. This inconsistency may be partly due to inadequate adjustment for several confounders such as cigarette smoking, alcohol consumption, physical activity, socioeconomic status and underlying diseases. Most studies have suggested that elevated body mass index (BMI) was associated with the risk of death from all cause and from specific causes. There was little evidence illustrating the effect of BMI on the mortality in elderly hypertensive patients in Chinese population
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
