Association of blood lipid and genetic factor with cancer risk in men

Abstract

Objective To investigate the potential roles of blood lipid levels and genetic factors in cancer development in men. Methods Male participants in the UK Biobank (UKB) were stratified into low, intermediate and high genetic risk groups. The number of abnormal lipid levels was used to divide study subjects into three categories. The association between abnormal levels of blood lipid and the risk of cancer incidence under different genetic risks were analyzed. Results A total of 178 171 men were included in the study, of whom 11 824 (6.64%) developed new cancer cases within the follow-up period. After adjustment for confounders including age, smoking, alcohol consumption, and fasting plasma glucose, abnormal lipid score was associated with the risk of cancer (all P Conclusion Abnormal levels of blood lipid may increase the risk of cancer across different genetic risk groups in men.