Association of blood heavy metal levels with osteocalcin abnormality and incidence of osteoporosis in Saudi subjects.

A A Banjabi,J M Yousef,K Kannan,T A Kumosani,S S Moselhy,K O Abulnaja

doi:10.1590/1519-6984.248828

A A Banjabi, J M Yousef + Show 4 more

Open Access

https://doi.org/10.1590/1519-6984.248828

Copy DOI

Abstract

Serum toxic metals have been implicated in development of many diseases. This study investigated the association between blood levels of lead and cadmium with abnormal bone mineral density (BMD) and incidence of osteoporosis. Sixty Saudi male adults age matching were assigned into two groups: A healthy control group (n = 30) and osteoporosis patients diagnosed according to T-score (n = 30). Serum calcium, vitamin D, osteocalcin, lead, cadmium were measured. Osteoporotic group showed a highly significant elevation of blood lead and cadmium levels compared to the control group (p <0.001). BMD was negatively correlated with serum osteocalcin level compared with control. There was a significant negative correlation between the cadmium and lead levels (r=-0.465 and p-value = 0.01) and calcium (p < 0.004). Our findings suggested that high cadmium and lead were negative correlated to BMD and increased the risk factor for osteoporosis.

Highlights

Environmental pollution causes a significant global problem for human health
Sixty Saudi subjects were included in this study, age and sex-matched. They were divided into two groups, 30 osteoproteic patients according to T-score, whereas the other group was comprised of 30 healthy participants from the general population with no reported symptoms of osteoporosis, following bone mineral density (BMD) measurements using dual energy X-ray absorptiometry (DEXA)
BMD of all individuals was measured by DEXA scan (Jeddah, Saudi Arabia)

Summary

Introduction

Environmental pollution causes a significant global problem for human health. Over the years, our environment has been filled with pollutants. People are frequently exposed to different kinds of environmental contaminants which are linked to deleterious effects on public health worldwide. Cadmium (Cd) and lead (Pb) are considered as chemical pollutants that require close monitoring (Mol, 2011). They are widely distributed in the environment (Madeddu et al., 2011), and contaminating the air, water, food sources and soil.

Methods

Results

Conclusion