Association of baseline C-reactive protein, D-dimer, and lymphocytes levels with health-related quality of life in severe COVID-19 survivors

Abstract

This study examined the association between baseline inflammatory markers and HrQoL (assessment using the SF-36 instrument) in severe COVID-19 survivors with cross-sectional observational analysis. The total subject is 80 people. Poor HrQoL findings based on the Physical Component Summary (PCS) were seen in 22 individuals (27.5%), and poor HrQoL findings based on the Mental Component Summary (MCS) were seen in 22 individuals (27.5%). The results showed that eight subjects (47.1%) with high D-dimer levels had poor PCS and MCS scores, with the same PR 2.1 (CI 95% 1.069-4.196;p=0.042). High levels of D-dimer and a duration of 12-16 weeks of confirmation were independently associated with PCS values ​​with PR values ​​of 5.5 (95% CI 1.190 – 25.144;p=0.029) and 4.5 (95% CI 1.402 – 14.647; p= 0.012). Meanwhile, a history of not taking routine medication for the treatment of comorbid diseases was a predictor that was independently associated with the MCS value, PR 0.3 (95% CI 0.115 – 0.956; p=0.041). This conclusion is CRP; absolute lymphocyte levels were not associated with HrQoL of severe COVID-19 survivors.