Abstract
Background:The association of genetic polymorphisms at Axis inhibition protein 2 (AXIN2) gene and susceptibility to different cancer has attracted much interest. The present study aimed to evaluate the association between AXIN2 rs2240308 C>T, rs1133683 C>T, rs7224837 A>G polymorphisms with susceptibility to breast cancer. Methods:A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was designed to genotype the AXIN2 rs2240308 C>T, rs1133683 C>T, rs7224837 A>G polymorphisms among 150 breast cancer patients and 150 healthy subjects. Results:The frequencies of these genetic variants were in agreement with Hardy-Weinberg equilibrium in healthy controls (p>0.05). The frequencies of AXIN2 rs2240308 C>T, rs1133683 C>T, rs7224837 A>G genotypes were similar in breast cancer patients and controls. There was no a significant association between the AXIN2 SNP and risk of breast cancer. Conclusion:The impact of AXIN2 polymorphisms in the breast cancer development remains unclear. Our results indicated that AXIN2 rs2240308, rs7224837 and rs1133683 polymorphisms did not contribute to increased risk of breast cancer. More studies with larger sample sizes and diverse ethnicities are warranted to verify our finding.
Highlights
Breast cancer is the most common type of epithelial cancer among women globally, with an average risk of 12% to develop in normal women life (Tavakoli-Koopaei et al, 2020; Najminejad et al, 2020; Ghorbani et al, 2021)
The present study aimed to evaluate the association between Axis inhibition protein 2 (AXIN2) rs2240308 C>T, rs1133683 C>T, rs7224837 A>G polymorphisms with susceptibility to breast cancer
Our results indicated that AXIN2 rs2240308, rs7224837 and rs1133683 polymorphisms did not contribute to increased risk of breast cancer
Summary
Breast cancer is the most common type of epithelial cancer among women globally, with an average risk of 12% to develop in normal women life (Tavakoli-Koopaei et al, 2020; Najminejad et al, 2020; Ghorbani et al, 2021). Breast cancer has the highest incidence rate and the second death rates among all types of cancer (Motamedi et al, 2012; Sung et al, 2021). The incidence of breast cancer has been increasing in the world where it accounts for 6.9% of all cancers and 684,996 deaths in 2020 (Esmaeili et al, 2021; Sung et al, 2021). The association of genetic polymorphisms at Axis inhibition protein 2 (AXIN2) gene and susceptibility to different cancer has attracted much interest. The present study aimed to evaluate the association between AXIN2 rs2240308 C>T, rs1133683 C>T, rs7224837 A>G polymorphisms with susceptibility to breast cancer. Our results indicated that AXIN2 rs2240308, rs7224837 and rs1133683 polymorphisms did not contribute to increased risk of breast cancer. More studies with larger sample sizes and diverse ethnicities are warranted to verify our finding
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