Association of autoantibodies anti-OxLDL and markers of inflammation with stage of HIV infection

Abstract

HIV infected individuals show a wide spectrum of changes caused by systemic immunosuppression homing from the virus itself or therapies used to improve this state. Uncontrolled replication of the virus causes changes in lipid profile, such as increased levels of triglycerides, low density lipoprotein and decreased high density lipoprotein, to promote a dyslipidemia condition [1]. Oxidative stress is also elevated in HIV+ patients due to excessive production of free radicals that play a major role in oxidative modification in LDL particle [2]. HIV+ patients with low counts of T CD4 cells show reduced plasma levels of anti-LDLm (LDL modified), and these low levels of antibodies are also associated with the lipodystrophy syndrome[3].SerumlevelsofOxLDLarehigherinHIV+patientsonantiretroviral therapy especially in patients with lipodystrophy syndrome compared with soronegative patients [4]. There are also other types of disorders that are frequent in HIV infection, such as endothelial dysfunction and metabolic disorders including insulin resistance [5]. All these factors increase the risk of HIV+ patients to accelerate the progression of the atherosclerosis. In this cross-section study, we included consecutive 69 adult patients of both gender with sorological positive to HIV infection. In HIV-infectedindividouswereevaluatedimmunemarkers,HIVinfection