Abstract
ObjectivesAtrial remodeling is the main developmental cause of atrial arrhythmias (AA), which may induce atrial fibrillation, atrial flutter, atrial tachycardia, and frequent premature atrial beats in acute myocardial infarction (AMI) patients. Thrombospondin-1 (TSP-1) has been shown to play an important role in inflammatory and fibrotic processes, but its role in atrial arrhythmias is not well described. The purpose of this study was to investigate the role of TSP-1 in AMI patients with atrial arrhythmias.MethodsA total of 219 patients with AMI who underwent percutaneous coronary intervention and with no previous arrhythmias were included. TSP-1 were analyzed in plasma samples. Patients were classified into 2 groups, namely, with and without AA during the acute phase of MI. Continuous electrocardiographic monitoring was used for AA diagnosis in hospital.ResultsTwenty-four patients developed AA. Patients with AA had higher TSP-1 levels (29.01 ± 25.87 μg/mL vs 18.36 ± 10.89 μg/mL, p < 0.001) than those without AA. AA patients also tended to be elderly (65.25 ± 9.98 years vs 57.47 ± 10.78 years, p < 0.001), had higher Hs-CRP (39.74 ± 43.50 mg/L vs 12.22 ± 19.25 mg/L, p < 0.001) and worse heart function. TSP-1 (OR 1.033; 95% CI 1.003–1.065, p = 0.034), Hs-CRP (OR 1.023; 95% CI 1.006–1.041, p = 0.008), age (OR 1.067; 95% CI 1.004–1.135, p = 0.038) and LVDd (OR 1.142; 95% CI 1.018–1.282, p = 0.024) emerged as independent risk factors for AA in AMI patients.ConclusionTSP-1 is a potential novel indicator of atrial arrhythmias during AMI.Graphical abstract
Highlights
Atrial fibrillation (AF) is one the most frequently encountered arrhythmias
Atrial arrhythmias (AA) are a group of supraventricular arrhythmias including atrial flutter, atrial tachycardia, and premature atrial beats that may eventually develop into AF and requires anticoagulation therapy [1]
Atrial arrhythmias were defined as the presentation of any kind of atrial electrical abnormalities, including atrial fibrillation, atrial flutter, atrial tachycardia, and premature atrial beats (> 200 beats/day) [15]
Summary
Atrial fibrillation (AF) is one the most frequently encountered arrhythmias. AF affects ~ 33 million worldwide, and both its incidence and associated mortality are increasing. Atrial arrhythmias (AA) are a group of supraventricular arrhythmias including atrial flutter, atrial tachycardia, and premature atrial beats that may eventually develop into AF and requires anticoagulation therapy [1]. Acute myocardial infarction (AMI) is one of the most common causes of death worldwide. It is often complicated by supraventricular arrhythmias, the most frequent of which is AF. Patients with AF in AMI have more comorbidities and are at greater risk of reinfarction, strokes, heart failure, and sudden cardiac death [3, 4]. Atrial arrhythmias (AA) like atrial flutter, atrial tachycardia, and premature atrial contractions (PACs) may develop into AF, increasing the risks mentioned previously [5, 6]. Other atrial arrhythmias may have been ignored, despite possibly similar inflammatory mechanisms that eventually lead to atrial remodeling
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
