Abstract
Previous studies have shown that angiotensin II AT1 receptor gene (AT1R) polymorphisms are associated with the risk for hypertension. However, the results remain controversial. In the present study, we performed a meta-analysis to systematically summarize the association between AT1R genetic polymorphisms and the risk for hypertension. We searched the literature in PubMed, EMBASE, ISI Web of Science, Wanfang, and Chinese National Knowledge Infrastructure databases (CNKI) to find case-control studies on the associations of AT1R genetic polymorphisms with the risk for hypertension. The meta-analysis was performed by using RevMan 5.0 software. The association of hypertension risk with AT1R genetic polymorphism was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Fifty-six studies involving 28,952 subjects were included in the present meta-analysis. Our results suggest that the polymorphism (A1166C) of AT1R gene is associated with a statistically increased hypertension risk, not only in Asian populations but also in Caucasian populations. We did not find any association in African populations. This meta-analysis suggests that A1166C polymorphism in the AT1R gene is associated with the risk of hypertension in Asian and Caucasian populations.
Highlights
Hypertension is a major public health problem throughout the world.[1]
A single nucleotide polymorphism (SNP), A1166C, is the most studied variant being located in the 3′ untranslated region of the AT1 receptor gene (AT1R) gene.[10]
A total of 447 articles concerning the AT1R A1166C polymorphism and hypertension were retrieved after first search in PubMed, EMBASE, ISI Web of Science, Wanfang in China, and Chinese National Knowledge Infrastructure databases (CNKI) databases
Summary
Hypertension is a major public health problem throughout the world.[1]. the pathogenesis of hypertension remains unclear. It is considered that hypertension is a complex disease resulting from the interaction between genetic polymorphisms and environmental factors.[2] Recently, many genes have been identified as candidates for contribution to hypertension.[3] Of these, the angiotensin II AT1 receptor (AT1R) plays an important role in normal blood pressure regulation and in the pathophysiological progression of hypertension.[4,5,6] The polymorphisms of the AT1R gene have been reported to be associated with the pathogenesis of hypertension.[7,8,9] In particular, a single nucleotide polymorphism (SNP), A1166C, is the most studied variant being located in the 3′ untranslated region of the AT1R gene.[10]. Previous studies have shown that angiotensin II AT1 receptor gene (AT1R) polymorphisms are associated with the risk for hypertension. We performed a metaanalysis to systematically summarize the association between AT1R genetic polymorphisms and the risk for hypertension
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