Abstract
BackgroundKidney impairment constitutes severe risk for cardiovascular disease, stroke and all-cause mortality, and early identification and prevention of kidney impairment is critical to effective management of prognostic risk in community residents. Previous studies have validated that carotid-femoral pulse wave velocity (cfPWV) is a significant factor associated with chronic kidney disease. However, whether cfPWV is associated with moderately reduced glomerular filtration rate (GFR) remains unclear. This analysis was designed to examine the association of moderately reduced GFR with cfPWV and central pulse pressure (cPP) in Chinese middle-aged and elderly community residents.MethodsThere were 875 community residents enrolled in this analysis, and then cfPWV and cPP were assessed in all participants following the standard procedure.ResultsEntire cohort had a median (range) age of 66 (45–88) years, and 65.4% were women. Both cfPWV and cPP differed significantly between participants with and without moderately reduced GFR (P < 0.05 for all). Logistic regression analyses indicated that cfPWV and cPP had the significant association with moderately reduced GFR (P < 0.05 for all).ConclusionThis analysis demonstrated the significant association of cfPWV and cPP with moderately reduced GFR in Chinese middle-aged and elderly community residents.
Highlights
Kidney impairment constitutes severe risk for cardiovascular disease, stroke and all-cause mortality, and early identification and prevention of kidney impairment is critical to effective management of prognostic risk in community residents
Several reports have indicated the evidence of chronic kidney disease (CKD) present in patients with abnormal central hemodynamics indicated by elevated central pulse pressure [5,6,7]
glomerular filtration rate (GFR) was significantly correlated with age, high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein-cholesterol (LDL-c), carotid-femoral pulse wave velocity (cfPWV), central pulse pressure (cPP) and peripheral pulse pressure (pPP) (P < 0.05 for all)
Summary
Kidney impairment constitutes severe risk for cardiovascular disease, stroke and all-cause mortality, and early identification and prevention of kidney impairment is critical to effective management of prognostic risk in community residents. Previous studies have validated that carotid-femoral pulse wave velocity (cfPWV) is a significant factor associated with chronic kidney disease. Whether cfPWV is associated with moderately reduced glomerular filtration rate (GFR) remains unclear. This analysis was designed to examine the association of moderately reduced GFR with cfPWV and central pulse pressure (cPP) in Chinese middle-aged and elderly community residents. Recent study has suggested that cPP rather than peripheral pulse pressure (pPP) is reflective of CKD [8]. Whether both cPP and pPP are closely associated with moderately reduced GFR is unclear, especially in. This analysis was designed to: 1) assess the association between cfPWV and moderately reduced GFR; and 2) observe the cPP and pPP in their association with moderately reduced GFR in Chinese middle-aged and elderly community residents
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