Abstract
This study evaluated the associations between job strain and arginase I in 378 healthy Japanese factory workers by a cross-sectional study measuring nitric oxide (NO)-related parameters (arginase I, L-arginine, exhaled nitric oxide (FeNO), and NOx), clinical parameters, and job strain using a Japanese version of the Job Content Questionnaire by Karasek. Arginase I and FEV1% were negatively correlated with job strain and positively correlated with job control and social support. FeNO and hs-CRP were negatively correlated with job strain. Multiple regression analysis showed negative association of arginase I with job strain and positive association with job control and social support in females. It is concluded that serum levels of arginase I may be useful biomarkers for the diagnosis of job stress in healthy female workers, although many factors can be influencing the data.
Highlights
Overwork-related stress has an effect on human health
Within the field of research on work stress, the demand-control model established by Karasek et al [3] is well known; this model predicts that biological aversive strain will occur when the psychological demands of the job exceed the resources for control over task content
The basic characteristics of the subjects by several clinical parameters and job strain in this study are presented in Table 1 and Table 2
Summary
Overwork-related stress has an effect on human health. In particular, sleep disturbance is the main complaint in work stress caused by overworking. Within the field of research on work stress, the demand-control model established by Karasek et al [3] is well known; this model predicts that biological aversive strain will occur when the psychological demands of the job exceed the resources for control over task content. This combination of high demands and low control produces job strain. In this study, we evaluated the interaction of arginase I with work stress in association with NO-related factors in healthy individuals of occupational workers
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