Abstract
Objective To investigate the relationship between c. 553G/T polymorphism of apolipoprotein A5 (ApoA5) gene and combined hyperlipidemia in Zunyi population. Methods Blood samples from 222 subjects including 100 patients with combined hyperlipidemia and 122 healthy individuals in Zunyi area were collected. c. 553G/T polymorphism was tested by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) assay in both groups. The distribution of the genotypes and allele frequencies in the combined hyperlipidemia group and normal control group were analyzed, and its relationship with combined hyperlipidemia was analyzed. Results The genotypes and gene frequencies of the ApoA5 gene c. 553G/T showed statistical difference between combined hyperlipidemia group and normal control group (χ2=12.081, P=0.001; χ2=17.469, P<0.001). The risk of hyperlipidemia for carriers of T alleles (TT or GT genotypes) was higher than those of GG genotypes (OR=6.042, 95% CI: 1.962-18.607, P=0.002), after adjusting age, gender and blood glucose by Logistic regression analysis. Conclusions ApoA5 gene c. 553G/T polymorphisms has a relationship with combined hyperlipidemia in Zunyi population. It may be an independent risk factor for combined hyperlipidemia. Key words: Apolipoprotein A5 gene; Polymorphism; Combined hyperlipidemia
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